Enhancement of in vivo anticancer effects of cisplatin by incorporation inside single-wall carbon nanohorns

Kumiko Ajima, Tatsuya Murakami, Yoshikazu Mizoguchi, Kunihiro Tsuchida, Toshinari Ichihashi, Sumio Iijima, Masako Yudasaka

研究成果: Article査読

201 被引用数 (Scopus)

抄録

Cisplatin (CDDP) was incorporated inside single-wall carbon nanohoms with holes opened (SWNHox) by a nanoprecipitation method that involved dispersion of CDDP and SWNHox in a solvent followed by the solvent evaporation. The incorporated CDDP quantity increased from the previously reported value of 15 to 46%, and the total released quantity of CDDP also increased from 60 to 100% by changing the solvent from dimethylformamide to water. Concurrently, in vitro anticancer efficiency of CDDPΣWNHox increased to 4-6 times greater than that of the intact CDDP. In vivo, CDDPΣWNHox intratumorally injected to transplanted tumors of mice suppressed the tumor growth more than the intact CDDP. We observed that CDDPΣWRHox adhered to the cell surfaces in vitro and stayed within the tumor tissues in vivo. Therefore, we think that the CDDP released from SWNHox realized high concentrations locally at the cells in vitro and in the tissues in vivo and could efficiently attack the tumor cells. We also found that SWNHox itself had an in vivo anticancer effect, which might increase the anticancer activities of CDDPΣWNHox.

本文言語English
ページ(範囲)2057-2064
ページ数8
ジャーナルACS Nano
2
10
DOI
出版ステータスPublished - 01-10-2008

All Science Journal Classification (ASJC) codes

  • 材料科学(全般)
  • 工学(全般)
  • 物理学および天文学(全般)

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