Enhancement of internal ribosome entry site-mediated translation and replication of hepatitis C virus by PD98059

Takayuki Murata, Makoto Hijikata, Kunitada Shimotohno

研究成果: Article査読

23 被引用数 (Scopus)

抄録

Translation initiation of hepatitis C virus (HCV) occurs in an internal ribosome entry site (IRES)-dependent manner. We found that HCV IRES-dependent protein synthesis is enhanced by PD98059, an inhibitor of the extracellular signal-regulated kinase (ERK) signaling pathway, while cellular cap-dependent translation was relatively unaffected by the compound. Treatment of cells with PD98059 allowed for robust HCV replication following cellular incubation with HCV-positive serum. Though the molecular mechanism underlying IRES enhancement remains elusive, PD98059 is a potent accelerator of HCV RNA replication.

本文言語English
ページ(範囲)105-115
ページ数11
ジャーナルVirology
340
1
DOI
出版ステータスPublished - 15-09-2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • Virology

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