Environmental enrichment alters gene expression of steroidogenic enzymes in the rat hippocampus

Eiji Munetsuna, Minoru Hattori, Yuya Sakimoto, Atsuhiko Ishida, Shogo Sakata, Yasushi Hojo, Suguru Kawato, Takeshi Yamazaki

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Neuroactive steroids are synthesized in the central and peripheral nervous systems. The purpose of this study was to analyze the effects of environmental enrichment on neuroactive steroidogenesis in the rat hippocampus. Environmental enrichment rats were housed in a group of nine in a large cage and three groups of pair-housed rats were housed in a standard cage for 8. weeks. The levels of mRNAs for steroidogenic enzymes and proteins in hippocampus were quantified by real-time RT-PCR. Environmental enrichment increased the mRNA expression levels of 5α-reductase-1 and 3α-hydroxysteroid dehydrogenase, which catalyze synthesis of allopregnanolone from progesterone. Hence, environmental enrichment appears to affect allopregnanolone synthesis.

本文言語English
ページ(範囲)28-32
ページ数5
ジャーナルGeneral and Comparative Endocrinology
171
1
DOI
出版ステータスPublished - 01-03-2011
外部発表はい

All Science Journal Classification (ASJC) codes

  • 動物科学および動物学
  • 内分泌学

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