TY - JOUR
T1 - Environmental enrichment alters gene expression of steroidogenic enzymes in the rat hippocampus
AU - Munetsuna, Eiji
AU - Hattori, Minoru
AU - Sakimoto, Yuya
AU - Ishida, Atsuhiko
AU - Sakata, Shogo
AU - Hojo, Yasushi
AU - Kawato, Suguru
AU - Yamazaki, Takeshi
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2011/3/1
Y1 - 2011/3/1
N2 - Neuroactive steroids are synthesized in the central and peripheral nervous systems. The purpose of this study was to analyze the effects of environmental enrichment on neuroactive steroidogenesis in the rat hippocampus. Environmental enrichment rats were housed in a group of nine in a large cage and three groups of pair-housed rats were housed in a standard cage for 8. weeks. The levels of mRNAs for steroidogenic enzymes and proteins in hippocampus were quantified by real-time RT-PCR. Environmental enrichment increased the mRNA expression levels of 5α-reductase-1 and 3α-hydroxysteroid dehydrogenase, which catalyze synthesis of allopregnanolone from progesterone. Hence, environmental enrichment appears to affect allopregnanolone synthesis.
AB - Neuroactive steroids are synthesized in the central and peripheral nervous systems. The purpose of this study was to analyze the effects of environmental enrichment on neuroactive steroidogenesis in the rat hippocampus. Environmental enrichment rats were housed in a group of nine in a large cage and three groups of pair-housed rats were housed in a standard cage for 8. weeks. The levels of mRNAs for steroidogenic enzymes and proteins in hippocampus were quantified by real-time RT-PCR. Environmental enrichment increased the mRNA expression levels of 5α-reductase-1 and 3α-hydroxysteroid dehydrogenase, which catalyze synthesis of allopregnanolone from progesterone. Hence, environmental enrichment appears to affect allopregnanolone synthesis.
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U2 - 10.1016/j.ygcen.2010.12.007
DO - 10.1016/j.ygcen.2010.12.007
M3 - Article
C2 - 21172348
AN - SCOPUS:79951509852
SN - 0016-6480
VL - 171
SP - 28
EP - 32
JO - General and Comparative Endocrinology
JF - General and Comparative Endocrinology
IS - 1
ER -