Epstein-Barr virus-positive cytotoxic T-cell lymphoma followed by chronic active Epstein-Barr virus infection-associated T/NK-cell lymphoproliferative disorder: A case report

Seiichi Kato, Tomoko Miyata, Katsuyoshi Takata, Satoko Shimada, Yoshinori Ito, Akihiro Tomita, Ahmed Ali Elsayed, Emiko Takahashi, Naoko Asano, Tomohiro Kinoshita, Hiroshi Kimura, Shigeo Nakamura

研究成果: Article査読

13 被引用数 (Scopus)

抄録

A 30-year-old female patient presented with intestinal Epstein-Barr virus (EBV)-positive cytotoxic T-cell lymphoma (EBV+ CTL), which was surgically resected. Fourteen years later, she returned to our hospital with hypersensitivity to mosquito bites and was diagnosed with chronic active EBV infection-associated T/NK-cell lymphoproliferative disorder (CAEBV/TNK-LPD). She developed systemic EBV+ CTL at age 47 years during the 2.5-year clinical course of CAEBV/TNK-LPD, despite multiagent chemotherapy and allogeneic stem cell transplantation. Afterward, she had a rapidly deteriorating clinical course and died at age 48 years. The immunophenotype of the EBV+ CTL was consistently a CD3, CD8, and cytotoxic molecule-positive type with the same clonality in polymerase chain reaction analysis of T-cell receptor-γ chain gene rearrangement. This is the first reported case of EBV+ CTL preceding the clinical presentation of CAEBV/TNK-LPD. The present case was unique in suggesting a close relationship between EBV+ CTL and chronic active EBV infection.

本文言語English
ページ(範囲)2849-2852
ページ数4
ジャーナルHuman Pathology
44
12
DOI
出版ステータスPublished - 12-2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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