抄録
To investigate the nature of the link between Helicobacter pylori (Hp) infection and stomach carcinogenesis, a study of the glandular stomach of Mongolian gerbils (MGs) was performed. MGs were treated with N-methyl-N- nitrosourea (MNU), followed by inoculation with Hp (groups 1 and 2) or without Hp (group 3), or infected with Hp (groups 4 and 5) or inoculation without Hp (group 6) followed by MNU administration. At week 21, the animals in groups 2 and 5 underwent an eradication procedure. At week 50, the incidences of adenocarcinomas in group 1 (15 of 23) and group 4 (9 of 26) were significantly higher than in group 3 (1 of 15) and group 6 (1 of 18), respectively. Moreover, those in group 2 (5 of 24) and group 5 (2 of 22) were lower than in groups 1 and 4, respectively. This study shows that Hp eradication may be useful as a prevention approach against stomach cancer.
本文言語 | 英語 |
---|---|
ページ(範囲) | 1512-1514 |
ページ数 | 3 |
ジャーナル | Cancer Research |
巻 | 60 |
号 | 6 |
出版ステータス | 出版済み - 15-03-2000 |
外部発表 | はい |
All Science Journal Classification (ASJC) codes
- 腫瘍学
- 癌研究