Eradication diminishes enhancing effects of Helicobacter pylori infection on glandular stomach carcinogenesis in Mongolian gerbils

Nobuyuki Shimizu, Yuzuru Ikehara, Ken Ichi Inada, Hayao Nakanishi, Tetsuya Tsukamoto, Koji Nozaki, Michio Kaminishi, Shu Kuramoto, Atsushi Sugiyama, Tsutomu Katsuyama, Masae Tatematsu

研究成果: ジャーナルへの寄稿学術論文査読

153 被引用数 (Scopus)

抄録

To investigate the nature of the link between Helicobacter pylori (Hp) infection and stomach carcinogenesis, a study of the glandular stomach of Mongolian gerbils (MGs) was performed. MGs were treated with N-methyl-N- nitrosourea (MNU), followed by inoculation with Hp (groups 1 and 2) or without Hp (group 3), or infected with Hp (groups 4 and 5) or inoculation without Hp (group 6) followed by MNU administration. At week 21, the animals in groups 2 and 5 underwent an eradication procedure. At week 50, the incidences of adenocarcinomas in group 1 (15 of 23) and group 4 (9 of 26) were significantly higher than in group 3 (1 of 15) and group 6 (1 of 18), respectively. Moreover, those in group 2 (5 of 24) and group 5 (2 of 22) were lower than in groups 1 and 4, respectively. This study shows that Hp eradication may be useful as a prevention approach against stomach cancer.

本文言語英語
ページ(範囲)1512-1514
ページ数3
ジャーナルCancer Research
60
6
出版ステータス出版済み - 15-03-2000
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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