Eradication of Helicobacter pylori Induces Immediate Regressive Changes in Early Gastric Adenocarcinomas

Mitsuru Nakagawa, Yasuhiro Sakai, Yuka Kiriyama, Tomomitsu Tahara, Noriyuki Horiguchi, Asako Okabe, Sayumi Tahara, Tomoyuki Shibata, Naoki Omiya, Makoto Kuroda, Atsushi Sugioka, Tetsuya Tsukamoto

研究成果: Article

抄録

Objective: Helicobacter pylori eradication is expected to prevent gastric cancer. However, morphological alterations after eradication often hinder accurate diagnosis. Therefore, we evaluated endoscopic and histological changes in gastric tumors after eradication of H. pylori in a time-dependent manner. Methods: We classified 144 cases of endoscopic submucosal dissection (ESD) of early gastric cancer into the following categories: (i) patients positive for H. pylori with no eradication history, (ii) patients positive for H. pylori who underwent ESD 2 months after eradication, (iii) patients negative for H. pylori with an eradication history of at least 6 months before ESD, and (iv) patients negative for H. pylori with an unknown history. We compared endoscopic and histological factors between the groups. Results: The characteristics of cancers positive for H. pylori were exploding shape, superficial high-grade atypical epithelium, and a surface proliferating zone. H. pylori eradication induced a series of endoscopic and histological changes, including shape -depression, appearance of surface regenerative and lower-grade atypical epithelium, and a downward shift of the proliferative zone within a period as short as 2 months. Conclusion: H. pylori eradication rapidly causes cancer regression and leads to tumor shrinkage, diminished atypism, and shortened proliferative zone, resulting in drastic morphological changes.

元の言語English
ページ(範囲)135-144
ページ数10
ジャーナルPathobiology
86
発行部数2-3
DOI
出版物ステータスPublished - 01-06-2019

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Helicobacter pylori
Stomach
Adenocarcinoma
Stomach Neoplasms
Neoplasms
Epithelium
History
Endoscopic Mucosal Resection

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

これを引用

Nakagawa, M., Sakai, Y., Kiriyama, Y., Tahara, T., Horiguchi, N., Okabe, A., ... Tsukamoto, T. (2019). Eradication of Helicobacter pylori Induces Immediate Regressive Changes in Early Gastric Adenocarcinomas. Pathobiology, 86(2-3), 135-144. https://doi.org/10.1159/000496692
Nakagawa, Mitsuru ; Sakai, Yasuhiro ; Kiriyama, Yuka ; Tahara, Tomomitsu ; Horiguchi, Noriyuki ; Okabe, Asako ; Tahara, Sayumi ; Shibata, Tomoyuki ; Omiya, Naoki ; Kuroda, Makoto ; Sugioka, Atsushi ; Tsukamoto, Tetsuya. / Eradication of Helicobacter pylori Induces Immediate Regressive Changes in Early Gastric Adenocarcinomas. :: Pathobiology. 2019 ; 巻 86, 番号 2-3. pp. 135-144.
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abstract = "Objective: Helicobacter pylori eradication is expected to prevent gastric cancer. However, morphological alterations after eradication often hinder accurate diagnosis. Therefore, we evaluated endoscopic and histological changes in gastric tumors after eradication of H. pylori in a time-dependent manner. Methods: We classified 144 cases of endoscopic submucosal dissection (ESD) of early gastric cancer into the following categories: (i) patients positive for H. pylori with no eradication history, (ii) patients positive for H. pylori who underwent ESD 2 months after eradication, (iii) patients negative for H. pylori with an eradication history of at least 6 months before ESD, and (iv) patients negative for H. pylori with an unknown history. We compared endoscopic and histological factors between the groups. Results: The characteristics of cancers positive for H. pylori were exploding shape, superficial high-grade atypical epithelium, and a surface proliferating zone. H. pylori eradication induced a series of endoscopic and histological changes, including shape -depression, appearance of surface regenerative and lower-grade atypical epithelium, and a downward shift of the proliferative zone within a period as short as 2 months. Conclusion: H. pylori eradication rapidly causes cancer regression and leads to tumor shrinkage, diminished atypism, and shortened proliferative zone, resulting in drastic morphological changes.",
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Nakagawa, M, Sakai, Y, Kiriyama, Y, Tahara, T, Horiguchi, N, Okabe, A, Tahara, S, Shibata, T, Omiya, N, Kuroda, M, Sugioka, A & Tsukamoto, T 2019, 'Eradication of Helicobacter pylori Induces Immediate Regressive Changes in Early Gastric Adenocarcinomas', Pathobiology, 巻. 86, 番号 2-3, pp. 135-144. https://doi.org/10.1159/000496692

Eradication of Helicobacter pylori Induces Immediate Regressive Changes in Early Gastric Adenocarcinomas. / Nakagawa, Mitsuru; Sakai, Yasuhiro; Kiriyama, Yuka; Tahara, Tomomitsu; Horiguchi, Noriyuki; Okabe, Asako; Tahara, Sayumi; Shibata, Tomoyuki; Omiya, Naoki; Kuroda, Makoto; Sugioka, Atsushi; Tsukamoto, Tetsuya.

:: Pathobiology, 巻 86, 番号 2-3, 01.06.2019, p. 135-144.

研究成果: Article

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T1 - Eradication of Helicobacter pylori Induces Immediate Regressive Changes in Early Gastric Adenocarcinomas

AU - Nakagawa, Mitsuru

AU - Sakai, Yasuhiro

AU - Kiriyama, Yuka

AU - Tahara, Tomomitsu

AU - Horiguchi, Noriyuki

AU - Okabe, Asako

AU - Tahara, Sayumi

AU - Shibata, Tomoyuki

AU - Omiya, Naoki

AU - Kuroda, Makoto

AU - Sugioka, Atsushi

AU - Tsukamoto, Tetsuya

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Objective: Helicobacter pylori eradication is expected to prevent gastric cancer. However, morphological alterations after eradication often hinder accurate diagnosis. Therefore, we evaluated endoscopic and histological changes in gastric tumors after eradication of H. pylori in a time-dependent manner. Methods: We classified 144 cases of endoscopic submucosal dissection (ESD) of early gastric cancer into the following categories: (i) patients positive for H. pylori with no eradication history, (ii) patients positive for H. pylori who underwent ESD 2 months after eradication, (iii) patients negative for H. pylori with an eradication history of at least 6 months before ESD, and (iv) patients negative for H. pylori with an unknown history. We compared endoscopic and histological factors between the groups. Results: The characteristics of cancers positive for H. pylori were exploding shape, superficial high-grade atypical epithelium, and a surface proliferating zone. H. pylori eradication induced a series of endoscopic and histological changes, including shape -depression, appearance of surface regenerative and lower-grade atypical epithelium, and a downward shift of the proliferative zone within a period as short as 2 months. Conclusion: H. pylori eradication rapidly causes cancer regression and leads to tumor shrinkage, diminished atypism, and shortened proliferative zone, resulting in drastic morphological changes.

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