Essential role of placental leucine aminopeptidase in gynecologic malignancy

Shigehiko Mizutani, Kiyosumi Shibata, Fumitaka Kikkawa, Akira Hattori, Masafumi Tsujimoto, Masakazu Ishii, Hiroshi Kobayashi

研究成果: Review article査読

30 被引用数 (Scopus)

抄録

The M1 aminopeptidase family is important for the maturation or degradation of bioactive peptides by hydrolyzing their N-terminal amino acids. Some investigators have studied aminopeptidase in the maintenance of homeostasis including maintenance of normal pregnancy, memory retention, blood pressure regulation and antigen presentation. However, there are a few reports on the relation between the M1 aminopeptidase family and carcinoma. In addition to its capacity to degrade a range of peptides, placental-leucine aminopeptidase (P-LAP) has novel functions that impact on normal cells and neoplastic cells. P-LAP is the focus of this review.

本文言語English
ページ(範囲)453-461
ページ数9
ジャーナルExpert Opinion on Therapeutic Targets
11
4
DOI
出版ステータスPublished - 01-04-2007
外部発表はい

All Science Journal Classification (ASJC) codes

  • 分子医療
  • 薬理学
  • 創薬
  • 臨床生化学

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