Establishment of a new cell line of endometrioid carcinoma of the ovary and its chemosensitivity

Tomokazu Umezu; Hiroaki Kajiyama; Mikio Terauchi; Kiyosumi Shibata; Kazuhiko Ino; Akihiro Nawa; Fumitaka Kikkawa

doi:10.1111/j.1749-0774.2007.00030.x

Establishment of a new cell line of endometrioid carcinoma of the ovary and its chemosensitivity

Tomokazu Umezu, Hiroaki Kajiyama, Mikio Terauchi, Kiyosumi Shibata, Kazuhiko Ino, Akihiro Nawa, Fumitaka Kikkawa

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

10 被引用数 (Scopus)

抄録

A new cell line (NOE) of human ovarian endometrioid carcinoma was established and characterized. The cell line showed a short spindle-shaped morphology and continued to grow for more than 4 months without contact inhibition. The doubling time was approximately 15.5 h at the 10th passage. The chromosome number was aneuploid. The IC50 values of paclitaxel, cisplatin and carboplatin were 26.4 ng/mL, 2.4 μg/mL and 32.5 μg/mL, respectively. The NOE cells expressed estrogen receptor α. In nude mice, we confirmed tumor formation of NOE cells. These results indicated that NOE cells showed similar chemosensitivity and properties to those of the original tumor and might be useful in basic studies on the diagnosis, treatment and etiology of ovarian tumors.

本文言語	英語
ページ（範囲）	71-76
ページ数	6
ジャーナル	Human Cell
巻	20
号	3
DOI	https://doi.org/10.1111/j.1749-0774.2007.00030.x
出版ステータス	出版済み - 08-2007
外部発表	はい

All Science Journal Classification (ASJC) codes

細胞生物学
癌研究

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1111/j.1749-0774.2007.00030.x

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title = "Establishment of a new cell line of endometrioid carcinoma of the ovary and its chemosensitivity",

abstract = "A new cell line (NOE) of human ovarian endometrioid carcinoma was established and characterized. The cell line showed a short spindle-shaped morphology and continued to grow for more than 4 months without contact inhibition. The doubling time was approximately 15.5 h at the 10th passage. The chromosome number was aneuploid. The IC50 values of paclitaxel, cisplatin and carboplatin were 26.4 ng/mL, 2.4 μg/mL and 32.5 μg/mL, respectively. The NOE cells expressed estrogen receptor α. In nude mice, we confirmed tumor formation of NOE cells. These results indicated that NOE cells showed similar chemosensitivity and properties to those of the original tumor and might be useful in basic studies on the diagnosis, treatment and etiology of ovarian tumors.",

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AU - Umezu, Tomokazu

AU - Kajiyama, Hiroaki

AU - Terauchi, Mikio

AU - Shibata, Kiyosumi

AU - Ino, Kazuhiko

AU - Nawa, Akihiro

AU - Kikkawa, Fumitaka

PY - 2007/8

Y1 - 2007/8

N2 - A new cell line (NOE) of human ovarian endometrioid carcinoma was established and characterized. The cell line showed a short spindle-shaped morphology and continued to grow for more than 4 months without contact inhibition. The doubling time was approximately 15.5 h at the 10th passage. The chromosome number was aneuploid. The IC50 values of paclitaxel, cisplatin and carboplatin were 26.4 ng/mL, 2.4 μg/mL and 32.5 μg/mL, respectively. The NOE cells expressed estrogen receptor α. In nude mice, we confirmed tumor formation of NOE cells. These results indicated that NOE cells showed similar chemosensitivity and properties to those of the original tumor and might be useful in basic studies on the diagnosis, treatment and etiology of ovarian tumors.

AB - A new cell line (NOE) of human ovarian endometrioid carcinoma was established and characterized. The cell line showed a short spindle-shaped morphology and continued to grow for more than 4 months without contact inhibition. The doubling time was approximately 15.5 h at the 10th passage. The chromosome number was aneuploid. The IC50 values of paclitaxel, cisplatin and carboplatin were 26.4 ng/mL, 2.4 μg/mL and 32.5 μg/mL, respectively. The NOE cells expressed estrogen receptor α. In nude mice, we confirmed tumor formation of NOE cells. These results indicated that NOE cells showed similar chemosensitivity and properties to those of the original tumor and might be useful in basic studies on the diagnosis, treatment and etiology of ovarian tumors.

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Establishment of a new cell line of endometrioid carcinoma of the ovary and its chemosensitivity

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All Science Journal Classification (ASJC) codes

UN SDG

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