Establishment of a reverse genetics system for rotavirus

Satoshi Komoto, Koki Taniguchi

研究成果: ジャーナルへの寄稿総説査読

1 被引用数 (Scopus)

抄録

The rotavirus genome is composed of 11 segments of double-stranded RNA (dsRNA). Rotavirus is the leading etiological agent of severe gastroenteritis in infants and young children worldwide. Reverse genetics is the powerful and ideal methodology for the molecular study of virus replication, which enables the virus genome to be artificially manipulated. Very recently, we developed the first reverse genetics system for rotavirus, which enables one to generate an infectious rotavirus containing a novel gene segment derived from cDNA. In this review, we describe each steps of rotavirus replication to understand the background to the establishment of a reverse genetics system for rotavirus, and summarize the reverse genetics systems for segmented dsRNA viruses including rotavirus.

本文言語英語
ページ(範囲)183-192
ページ数10
ジャーナルUirusu. Journal of virology
56
2
DOI
出版ステータス出版済み - 12-2006

All Science Journal Classification (ASJC) codes

  • 医学一般

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