Establishment of thymoma-prone congenic rat strain, ACI.BUF/Mna-Tsr1/Tsr1

Mutsushi Matsuyama, Kazuo Kato, Kyoko Higo-Moriguchi, Tetsuji Yamada, Takashi Kuramoto, Makoto Kuroda

研究成果: ジャーナルへの寄稿学術論文査読

4 被引用数 (Scopus)

抄録

Purpose: To confirm the presence of the susceptible gene for the thymoma development in the region that was assumed by the previous linkage study by Oyabu et al. (J Natl Cancer Inst 91:279-282, 1999), we tried to establish a congenic strain of rats. Methods: Backcrossings between the BUF/Mna strain as a donor strain and the ACI/NMna strain as an inbred partner were repeated for 12 generations, examining whether rats had the thymoma development region, and then homozygous rats were yielded by mating among the heterozygotes. To detect the phenotypic expression, heterozygous ACI.BUF/Mna-Tsr1/+ (ACI-Tsr1/+) rats were generated by crossing female ACI.BUF/Mna-Tsr1/Tsr1 (ACI-Tsr1/Tsr1) rats with male ACI/NMna rats and were maintained for 24 months. Results: These ACI-Tsr1/+ rats produced thymoma in 71%, showing a dominant trait. The thymomas were of the lymphocyte predominant type, as those developed in rats of the original BUF/Mna strain. Conclusions: Thus, a new rat congenic strain, ACI-Tsr1/Tsr1, was established, revealing that thymoma develops in the dominant trait in ACI-Tsr1/+ rats.

本文言語英語
ページ(範囲)789-792
ページ数4
ジャーナルJournal of Cancer Research and Clinical Oncology
134
7
DOI
出版ステータス出版済み - 07-2008

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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