Evaluation of 2 scatter correction methods using a striatal phantom for quantitative brain SPECT

Douglass C. Vines, Masanori Ichise, Jeih San Liow, Hiroshi Toyama, Robert B. Innis

研究成果: Article査読

8 被引用数 (Scopus)


Objective: Scatter correction is an important factor in quantitative SPECT. In this study, we evaluated 2 methods of scatter correction for brain SPECT. The first is based on thresholding the energy spectrum (ES), and the second is based on a modification of the transmission-dependent convolution subtraction (TDCS) method. Methods: SPECT imaging of a skull striatal phantom was performed using a triple-head camera with and without scatter correction. The striatal compartments were filled with 123I, and the brain shell cavity (background) was filled with varying concentrations of 123I to obtain striatal-to-background ratios of 2, 5, 10, 15, 20, and 25 to 1, respectively, which were considered to be the expected ratios. SPECT-measured ratios of striatal-to-background counts were determined with scatter correction (both ES and TDCS methods) and without scatter correction and were then compared with the expected ratios. Results: Without scatter correction, measured striatal-to-background ratios were underestimated by an average of 41.7%, compared with the expected ratios. The ES method of scatter correction underestimated the striatal-to-background ratios by an average of 27.4%, a significant improvement (P < 0.04) over those without scatter correction. With the TDCS method of scatter correction, the ratios were underestimated by only 3.3% (P < 0.03). TDCS ratios were significantly (P < 0.04) higher than ES ratios and were nearly identical to the expected ratios. Conclusion: These results suggest that scatter correction significantly improves the striatal-to-background ratios. The TDCS method appears to correct scatter more effectively than does the ES method for the striatal phantom, thus providing more accurate quantification.

ジャーナルJournal of Nuclear Medicine Technology
出版ステータスPublished - 01-09-2003

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

フィンガープリント 「Evaluation of 2 scatter correction methods using a striatal phantom for quantitative brain SPECT」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。