Evaluation of anesthesia effects on [18F]FDG uptake in mouse brain and heart using small animal PET

Hiroshi Toyama, Masanori Ichise, Jeih San Liow, Douglass C. Vines, Nicholas M. Seneca, Kendra J. Modell, Jurgen Seidel, Michael V. Green, Robert B. Innis

研究成果: Article査読

116 被引用数 (Scopus)

抄録

This study evaluates effects of anesthesia on 18F-FDG (FDG) uptake in mouse brain and heart to establish the basic conditions of small animal PET imaging. Prior to FDG injection, 12 mice were anesthetized with isoflurane gas; 11 mice were anesthetized with an intraperitoneal injection of a ketamine/xylazine mixture; and 11 mice were awake. In isoflurane and ketamine/xylazine conditions, FDG brain uptake (%ID/g) was significantly lower than in controls. Conversely, in the isoflurane condition, %ID/g in heart was significantly higher than in controls, whereas heart uptake in ketamine/ xylazine mice was significantly lower. Results suggest that anesthesia impedes FDG uptake in mouse brain and affects FDG uptake in heart; however, the effects in the brain and heart differ depending on the type of anesthesia used.

本文言語English
ページ(範囲)251-256
ページ数6
ジャーナルNuclear Medicine and Biology
31
2
DOI
出版ステータスPublished - 02-2004
外部発表はい

All Science Journal Classification (ASJC) codes

  • 分子医療
  • 放射線学、核医学およびイメージング
  • 癌研究

フィンガープリント

「Evaluation of anesthesia effects on [<sup>18</sup>F]FDG uptake in mouse brain and heart using small animal PET」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル