TY - JOUR
T1 - Evaluation of BPA uptake in clear cell sarcoma (CCS) in vitro and development of an in vivo model of CCS for BNCT studies
AU - Fujimoto, T.
AU - Andoh, T.
AU - Sudo, T.
AU - Fujita, I.
AU - Imabori, M.
AU - Moritake, H.
AU - Sugimoto, T.
AU - Sakuma, Y.
AU - Takeuchi, T.
AU - Sonobe, H.
AU - Epstein, Alan L.
AU - Akisue, T.
AU - Kirihata, M.
AU - Kurosaka, M.
AU - Fukumori, Y.
AU - Ichikawa, H.
PY - 2011/12
Y1 - 2011/12
N2 - Clear cell sarcoma (CCS), a rare malignant tumor with a predilection for young adults, is of poor prognosis. Recently however, boron neutron capture therapy (BNCT) with the use of p-borono-L-phenylalanine (BPA) for malignant melanoma has provided good results. CCS also produces melanin; therefore, the uptake of BPA is the key to the application of BNCT to CCS. We describe, for the first time, the high accumulation of boron in CCS and the CCS tumor-bearing animal model generated for BNCT studies.
AB - Clear cell sarcoma (CCS), a rare malignant tumor with a predilection for young adults, is of poor prognosis. Recently however, boron neutron capture therapy (BNCT) with the use of p-borono-L-phenylalanine (BPA) for malignant melanoma has provided good results. CCS also produces melanin; therefore, the uptake of BPA is the key to the application of BNCT to CCS. We describe, for the first time, the high accumulation of boron in CCS and the CCS tumor-bearing animal model generated for BNCT studies.
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U2 - 10.1016/j.apradiso.2011.02.006
DO - 10.1016/j.apradiso.2011.02.006
M3 - Article
C2 - 21354804
AN - SCOPUS:80055074934
SN - 0969-8043
VL - 69
SP - 1713
EP - 1716
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
IS - 12
ER -