Evaluation of insulin independence using 11c-methionine positron emission tomography after living-donor and brain-dead donor pancreas transplantation

K. Otsuki, K. Yoshikawa, T. Kenmoshi, N. Akutsu, M. Maruyama, T. Asano, K. Saigo, M. Hasegawa, H. Aoyama, I. Matsumoto, T. Ito, Y. Uchino

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We recently reported that 11C-methionine positron-emission tomography (PET) is clinically useful for the evaluation of the pancreatic function of the living donor. The objective of this study was to evaluate the postoperative insulin independence in 10 living donor (LD) and 10 brain-dead donor (BD) pancreas transplantations for 20 patients with type I diabetes mellitus by using 11C-methionine PET. After 6 months, PET/computed tomography was performed 30 minutes after 11C-methionine (370-740 MBq) injection. The uptake in the pancreas was expressed as the standardized uptake value (SUV). Patient survival rates were 100% at 5 years for LD transplantations and at 2 years for BD transplantations. Insulin independence was 60% for LD transplantations at 5 years and 75% for BD transplantations at 2 years. There were no major surgical complications such as vascular thrombosis, intra-abdominal abscess, and graft pancreatitis. The SUVs for LD and BD pancreas transplantations with insulin independence were 7.2 ± 1.8 and 10.4 ± 2.3, respectively. The SUVs for LD pancreas transplantations with insulin dependence and BD pancreas transplantations with graft failure were 3.6 ± 1.1 and 2.9 ± 1.0, respectively. At 5 years after transplantation, for the LD transplants, the insulin-independent rate was 100% for the graft recipients with an SUV higher than 5, and the median insulin independence duration of the graft recipients with an SUV less than 5 was 7 months (P <.01). The 11C-methionine PET may be a potent modality to predict long-term insulin independence and the avoidance of pancreas graft failure.

元の言語English
ページ(範囲)1913-1916
ページ数4
ジャーナルTransplantation Proceedings
46
発行部数6
DOI
出版物ステータスPublished - 01-01-2014

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

これを引用

Otsuki, K., Yoshikawa, K., Kenmoshi, T., Akutsu, N., Maruyama, M., Asano, T., Saigo, K., Hasegawa, M., Aoyama, H., Matsumoto, I., Ito, T., & Uchino, Y. (2014). Evaluation of insulin independence using 11c-methionine positron emission tomography after living-donor and brain-dead donor pancreas transplantation. Transplantation Proceedings, 46(6), 1913-1916. https://doi.org/10.1016/j.transproceed.2014.05.069