TY - JOUR
T1 - Evaluation of insulin independence using 11c-methionine positron emission tomography after living-donor and brain-dead donor pancreas transplantation
AU - Otsuki, K.
AU - Yoshikawa, K.
AU - Kenmoshi, T.
AU - Akutsu, N.
AU - Maruyama, M.
AU - Asano, T.
AU - Saigo, K.
AU - Hasegawa, M.
AU - Aoyama, H.
AU - Matsumoto, I.
AU - Ito, T.
AU - Uchino, Y.
N1 - Funding Information:
This study was supported in part by a Grant-in-Aid (MEXT/JSPS KAKENHI 24591806) from the Ministry of Education, Science and Culture. The authors declare no conflict of interest.
PY - 2014
Y1 - 2014
N2 - We recently reported that 11C-methionine positron-emission tomography (PET) is clinically useful for the evaluation of the pancreatic function of the living donor. The objective of this study was to evaluate the postoperative insulin independence in 10 living donor (LD) and 10 brain-dead donor (BD) pancreas transplantations for 20 patients with type I diabetes mellitus by using 11C-methionine PET. After 6 months, PET/computed tomography was performed 30 minutes after 11C-methionine (370-740 MBq) injection. The uptake in the pancreas was expressed as the standardized uptake value (SUV). Patient survival rates were 100% at 5 years for LD transplantations and at 2 years for BD transplantations. Insulin independence was 60% for LD transplantations at 5 years and 75% for BD transplantations at 2 years. There were no major surgical complications such as vascular thrombosis, intra-abdominal abscess, and graft pancreatitis. The SUVs for LD and BD pancreas transplantations with insulin independence were 7.2 ± 1.8 and 10.4 ± 2.3, respectively. The SUVs for LD pancreas transplantations with insulin dependence and BD pancreas transplantations with graft failure were 3.6 ± 1.1 and 2.9 ± 1.0, respectively. At 5 years after transplantation, for the LD transplants, the insulin-independent rate was 100% for the graft recipients with an SUV higher than 5, and the median insulin independence duration of the graft recipients with an SUV less than 5 was 7 months (P <.01). The 11C-methionine PET may be a potent modality to predict long-term insulin independence and the avoidance of pancreas graft failure.
AB - We recently reported that 11C-methionine positron-emission tomography (PET) is clinically useful for the evaluation of the pancreatic function of the living donor. The objective of this study was to evaluate the postoperative insulin independence in 10 living donor (LD) and 10 brain-dead donor (BD) pancreas transplantations for 20 patients with type I diabetes mellitus by using 11C-methionine PET. After 6 months, PET/computed tomography was performed 30 minutes after 11C-methionine (370-740 MBq) injection. The uptake in the pancreas was expressed as the standardized uptake value (SUV). Patient survival rates were 100% at 5 years for LD transplantations and at 2 years for BD transplantations. Insulin independence was 60% for LD transplantations at 5 years and 75% for BD transplantations at 2 years. There were no major surgical complications such as vascular thrombosis, intra-abdominal abscess, and graft pancreatitis. The SUVs for LD and BD pancreas transplantations with insulin independence were 7.2 ± 1.8 and 10.4 ± 2.3, respectively. The SUVs for LD pancreas transplantations with insulin dependence and BD pancreas transplantations with graft failure were 3.6 ± 1.1 and 2.9 ± 1.0, respectively. At 5 years after transplantation, for the LD transplants, the insulin-independent rate was 100% for the graft recipients with an SUV higher than 5, and the median insulin independence duration of the graft recipients with an SUV less than 5 was 7 months (P <.01). The 11C-methionine PET may be a potent modality to predict long-term insulin independence and the avoidance of pancreas graft failure.
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U2 - 10.1016/j.transproceed.2014.05.069
DO - 10.1016/j.transproceed.2014.05.069
M3 - Article
C2 - 25131069
AN - SCOPUS:84906077753
SN - 0041-1345
VL - 46
SP - 1913
EP - 1916
JO - Transplantation Proceedings
JF - Transplantation Proceedings
IS - 6
ER -