Evidence for a role of Collapsin response mediator protein-2 in signaling pathways that regulate the proliferation of non-neuronal cells

Candice Ginn T. Tahimic, Nozomi Tomimatsu, Ryuichi Nishigaki, Akiko Fukuhara, Tosifusa Toda, Kozo Kaibuchi, Goshi Shiota, Mitsuo Oshimura, Akihiro Kurimasa

研究成果: Article査読

38 被引用数 (Scopus)

抄録

Collapsin response mediator protein-2 or Crmp-2 plays a critical role in the establishment of neuronal polarity. In this study, we present evidence that apart from its functions in neurodevelopment, Crmp-2 is also involved in pathways that regulate the proliferation of non-neuronal cells through its phosphorylation by regulatory proteins. We show that Crmp-2 undergoes dynamic phosphorylation changes in response to contact inhibition-induced quiescence and that hyperphosphorylation of Crmp-2 occurs in a tumor. We further suggest that de-regulation of Crmp-2 phosphorylation levels at certain amino acid residues may lead to aberrant cell proliferation and consequently, tumorigenesis.

本文言語English
ページ(範囲)1244-1250
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
340
4
DOI
出版ステータスPublished - 24-02-2006
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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