Exacerbatory mechanism responsible for water immersion stress-induced gastric lesions in aged rats compared with young rats

Hidemi Goto, Kosuke Tachi, Yasuhiro Hisanaga, Kenji Kamiya, Naoki Ohmiya, Yasumasa Niwa, Tetsuo Hayakawa

研究成果: Article査読

11 被引用数 (Scopus)

抄録

1. The present study was designed to investigate whether or not ageing affects the development of water immersion stress-induced gastric lesions in rats. Effects of cetraxate, an anti-ulcer drug, were also examined. 2. Gastric lesions were induced by 6 h water immersion stress in rats. Gastric mucosal blood flow was determined by the hydrogen gas clearance technique and nitric oxide synthase (NOS) activity was measured enzymatically. 3. Early development of gastric lesions was observed in aged rats and exacerbation of gastric lesions was also found. Lowering of gastric mucosal blood flow and reduced NOS activity were observed in aged rats. 4. Cetraxate mitigated the development of gastric lesions in young rats and also increased gastric mucosal blood flow and NOS activity. However, these favourable effects were diminished in aged rats. 5. Decreased NOS activity may be an important exacerbatory factor to the development of gastric lesions in aged rats. 6. Effects of cetraxate differed between young rats and aged rats. 7. These results may explain the refractoriness and drug resistance in gastric ulcers encountered by elderly individuals.

本文言語English
ページ(範囲)659-662
ページ数4
ジャーナルClinical and Experimental Pharmacology and Physiology
28
8
DOI
出版ステータスPublished - 2001
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生理学
  • 薬理学
  • 生理学(医学)

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