Examination of percutaneous minocycline hydrochloride injection therapy for hepatic cyst by one puncture method

Yasuhito Tanaka, Masataka Ogino, Hiroshi Tokuda, Makoto Mizuno, Manabu Yamauchi, Yoshihiko Iijima, Kouhei Hattori, Takanobu Kato, Yuuko Komatsubara, Hideaki Kato, Katsumi Hayashi

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Minocycline hydrochloride (M1NO) at a dose of 500 mg (in principle) was injected into each of 11 hepatic cysts/10 cases (mean maximum diameter : 12.6 cm) that exhibited symptoms or a tendency toward growth by percutaneous transhepatic one puncture method, and the relation between therapeutic efficacy and pH of cystic fluid was examined. The efficacy was evaluated by abdominal CT after 3 months, and when a shrink of 50% or more in the maximum diameter was observed, it was judged as marked response. Marked effect was observed in 9 lesions of 11 (82%). This MINO injection therapy by one puncture method is very safe, simple and useful. Reduction in intra-cystic pH was not always related to the therapeutic efficacy, so involvement of cytotoxicity of MINO was suggested in degenerating the cystic epithelial cells.

本文言語English
ページ(範囲)828-836
ページ数9
ジャーナルJapanese Journal of Gastroenterology
93
11
出版ステータスPublished - 1996
外部発表はい

All Science Journal Classification (ASJC) codes

  • 消化器病学

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