Examination of serum pepsinogen in functional dyspepsia

Tomomitsu Tahara, Tomoyuki Shibata, Masaaki Okubo, Hiromi Yamashita, Daisuke Yoshioka, Joh Yonemura, Naoko Maruyama, Toshiaki Kamano, Yoshio Kamiya, Hiroshi Fujita, Yoshihito Nakagawa, Mitsuo Nagasaka, Masami Iwata, Hideto Yamada, Masakatsu Nakamura, Tomiyasu Arisawa, Ichiro Hirata

研究成果: Article

3 引用 (Scopus)

抄録

Background/Aims: Although serum pepsinogen (PG) is considered as a marker of gastric atrophy, it also reflects gastric acid secretion, which closely influences dyspeptic symptoms. We investigated serum PG levels and PGI/PGII ratios in dyspeptic patients, in relation to various different subtypes of symptoms including Rome III classifications. Methodology: Serum PGs were measured in 75 subjects with dyspeptic symptoms and 42 asymptomatic healthy subjects. Results: PG II level was significantly higher (p=0.0001) and PG I/II ratio was significantly lower (p<0.0001) in subjects with H. pylori infection than those without, while no associations were found between PG levels and usage of H2 receptor antagonists or proton-pump inhibitors. In all subjects with pain in stomach, abdominal bloating and PDS-like symptoms according to Rome III criteria, presented significantly higher levels of PGI, compared to subjects without symptoms (p=0.043, 0.015 and 0.037, respectively). In addition, burning sensation and abdominal pain presented significantly higher PGI/II ratios (p=0.0005 and 0.003, respectively), and higher PGI/II ratio was also positively correlated with a number of symptoms (p=0.04). When subjects were divided according to H. pylori infection status, higher PGI/II ratio was significantly associated with abdominal pain in H. pylori negative subjects (p=0.03), while higher PGI level was significantly associated with functional esophageal disorders (FEG) according to Rome III criteria, and higher number of dyspeptic symptoms in H. pylori positive subjects (p=0.016). Conclusions: Our data suggest that subjects with higher PGI level, and PG I/II ratio are more likely to develop several dyspeptic symptoms.

元の言語English
ページ(範囲)2516-2522
ページ数7
ジャーナルHepato-gastroenterology
59
発行部数120
DOI
出版物ステータスPublished - 01-11-2012

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Pepsinogen A
Dyspepsia
Pepsinogen C
Pylorus
Serum
Abdominal Pain
Stomach
Pain
Histamine H2 Receptors
Proton Pump Inhibitors
Gastric Acid
Infection
Atrophy
Healthy Volunteers

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

これを引用

Tahara, T., Shibata, T., Okubo, M., Yamashita, H., Yoshioka, D., Yonemura, J., ... Hirata, I. (2012). Examination of serum pepsinogen in functional dyspepsia. Hepato-gastroenterology, 59(120), 2516-2522. https://doi.org/10.5754/hge10604
Tahara, Tomomitsu ; Shibata, Tomoyuki ; Okubo, Masaaki ; Yamashita, Hiromi ; Yoshioka, Daisuke ; Yonemura, Joh ; Maruyama, Naoko ; Kamano, Toshiaki ; Kamiya, Yoshio ; Fujita, Hiroshi ; Nakagawa, Yoshihito ; Nagasaka, Mitsuo ; Iwata, Masami ; Yamada, Hideto ; Nakamura, Masakatsu ; Arisawa, Tomiyasu ; Hirata, Ichiro. / Examination of serum pepsinogen in functional dyspepsia. :: Hepato-gastroenterology. 2012 ; 巻 59, 番号 120. pp. 2516-2522.
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abstract = "Background/Aims: Although serum pepsinogen (PG) is considered as a marker of gastric atrophy, it also reflects gastric acid secretion, which closely influences dyspeptic symptoms. We investigated serum PG levels and PGI/PGII ratios in dyspeptic patients, in relation to various different subtypes of symptoms including Rome III classifications. Methodology: Serum PGs were measured in 75 subjects with dyspeptic symptoms and 42 asymptomatic healthy subjects. Results: PG II level was significantly higher (p=0.0001) and PG I/II ratio was significantly lower (p<0.0001) in subjects with H. pylori infection than those without, while no associations were found between PG levels and usage of H2 receptor antagonists or proton-pump inhibitors. In all subjects with pain in stomach, abdominal bloating and PDS-like symptoms according to Rome III criteria, presented significantly higher levels of PGI, compared to subjects without symptoms (p=0.043, 0.015 and 0.037, respectively). In addition, burning sensation and abdominal pain presented significantly higher PGI/II ratios (p=0.0005 and 0.003, respectively), and higher PGI/II ratio was also positively correlated with a number of symptoms (p=0.04). When subjects were divided according to H. pylori infection status, higher PGI/II ratio was significantly associated with abdominal pain in H. pylori negative subjects (p=0.03), while higher PGI level was significantly associated with functional esophageal disorders (FEG) according to Rome III criteria, and higher number of dyspeptic symptoms in H. pylori positive subjects (p=0.016). Conclusions: Our data suggest that subjects with higher PGI level, and PG I/II ratio are more likely to develop several dyspeptic symptoms.",
author = "Tomomitsu Tahara and Tomoyuki Shibata and Masaaki Okubo and Hiromi Yamashita and Daisuke Yoshioka and Joh Yonemura and Naoko Maruyama and Toshiaki Kamano and Yoshio Kamiya and Hiroshi Fujita and Yoshihito Nakagawa and Mitsuo Nagasaka and Masami Iwata and Hideto Yamada and Masakatsu Nakamura and Tomiyasu Arisawa and Ichiro Hirata",
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Tahara, T, Shibata, T, Okubo, M, Yamashita, H, Yoshioka, D, Yonemura, J, Maruyama, N, Kamano, T, Kamiya, Y, Fujita, H, Nakagawa, Y, Nagasaka, M, Iwata, M, Yamada, H, Nakamura, M, Arisawa, T & Hirata, I 2012, 'Examination of serum pepsinogen in functional dyspepsia', Hepato-gastroenterology, 巻. 59, 番号 120, pp. 2516-2522. https://doi.org/10.5754/hge10604

Examination of serum pepsinogen in functional dyspepsia. / Tahara, Tomomitsu; Shibata, Tomoyuki; Okubo, Masaaki; Yamashita, Hiromi; Yoshioka, Daisuke; Yonemura, Joh; Maruyama, Naoko; Kamano, Toshiaki; Kamiya, Yoshio; Fujita, Hiroshi; Nakagawa, Yoshihito; Nagasaka, Mitsuo; Iwata, Masami; Yamada, Hideto; Nakamura, Masakatsu; Arisawa, Tomiyasu; Hirata, Ichiro.

:: Hepato-gastroenterology, 巻 59, 番号 120, 01.11.2012, p. 2516-2522.

研究成果: Article

TY - JOUR

T1 - Examination of serum pepsinogen in functional dyspepsia

AU - Tahara, Tomomitsu

AU - Shibata, Tomoyuki

AU - Okubo, Masaaki

AU - Yamashita, Hiromi

AU - Yoshioka, Daisuke

AU - Yonemura, Joh

AU - Maruyama, Naoko

AU - Kamano, Toshiaki

AU - Kamiya, Yoshio

AU - Fujita, Hiroshi

AU - Nakagawa, Yoshihito

AU - Nagasaka, Mitsuo

AU - Iwata, Masami

AU - Yamada, Hideto

AU - Nakamura, Masakatsu

AU - Arisawa, Tomiyasu

AU - Hirata, Ichiro

PY - 2012/11/1

Y1 - 2012/11/1

N2 - Background/Aims: Although serum pepsinogen (PG) is considered as a marker of gastric atrophy, it also reflects gastric acid secretion, which closely influences dyspeptic symptoms. We investigated serum PG levels and PGI/PGII ratios in dyspeptic patients, in relation to various different subtypes of symptoms including Rome III classifications. Methodology: Serum PGs were measured in 75 subjects with dyspeptic symptoms and 42 asymptomatic healthy subjects. Results: PG II level was significantly higher (p=0.0001) and PG I/II ratio was significantly lower (p<0.0001) in subjects with H. pylori infection than those without, while no associations were found between PG levels and usage of H2 receptor antagonists or proton-pump inhibitors. In all subjects with pain in stomach, abdominal bloating and PDS-like symptoms according to Rome III criteria, presented significantly higher levels of PGI, compared to subjects without symptoms (p=0.043, 0.015 and 0.037, respectively). In addition, burning sensation and abdominal pain presented significantly higher PGI/II ratios (p=0.0005 and 0.003, respectively), and higher PGI/II ratio was also positively correlated with a number of symptoms (p=0.04). When subjects were divided according to H. pylori infection status, higher PGI/II ratio was significantly associated with abdominal pain in H. pylori negative subjects (p=0.03), while higher PGI level was significantly associated with functional esophageal disorders (FEG) according to Rome III criteria, and higher number of dyspeptic symptoms in H. pylori positive subjects (p=0.016). Conclusions: Our data suggest that subjects with higher PGI level, and PG I/II ratio are more likely to develop several dyspeptic symptoms.

AB - Background/Aims: Although serum pepsinogen (PG) is considered as a marker of gastric atrophy, it also reflects gastric acid secretion, which closely influences dyspeptic symptoms. We investigated serum PG levels and PGI/PGII ratios in dyspeptic patients, in relation to various different subtypes of symptoms including Rome III classifications. Methodology: Serum PGs were measured in 75 subjects with dyspeptic symptoms and 42 asymptomatic healthy subjects. Results: PG II level was significantly higher (p=0.0001) and PG I/II ratio was significantly lower (p<0.0001) in subjects with H. pylori infection than those without, while no associations were found between PG levels and usage of H2 receptor antagonists or proton-pump inhibitors. In all subjects with pain in stomach, abdominal bloating and PDS-like symptoms according to Rome III criteria, presented significantly higher levels of PGI, compared to subjects without symptoms (p=0.043, 0.015 and 0.037, respectively). In addition, burning sensation and abdominal pain presented significantly higher PGI/II ratios (p=0.0005 and 0.003, respectively), and higher PGI/II ratio was also positively correlated with a number of symptoms (p=0.04). When subjects were divided according to H. pylori infection status, higher PGI/II ratio was significantly associated with abdominal pain in H. pylori negative subjects (p=0.03), while higher PGI level was significantly associated with functional esophageal disorders (FEG) according to Rome III criteria, and higher number of dyspeptic symptoms in H. pylori positive subjects (p=0.016). Conclusions: Our data suggest that subjects with higher PGI level, and PG I/II ratio are more likely to develop several dyspeptic symptoms.

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Tahara T, Shibata T, Okubo M, Yamashita H, Yoshioka D, Yonemura J その他. Examination of serum pepsinogen in functional dyspepsia. Hepato-gastroenterology. 2012 11 1;59(120):2516-2522. https://doi.org/10.5754/hge10604