Exogenous antigens and the stimulation of MHC class I restricted cell-mediated cytotoxicity: Possible strategies for fish vaccines

Johannes M. Dijkstra, Uwe Fischer, Yoshihiro Sawamoto, Mitsuru Ototake, Teruyuki Nakanishi

研究成果: Review article査読

24 被引用数 (Scopus)

抄録

An MHC class I restricted cytotoxic T lymphocyte (CTL) activity assay has recently been established for rainbow trout. MHC class I restricted cytotoxicity probably plays a critical role in immunity to most viral diseases in mammals and may play a similar role in fish. Therefore, it is very important to investigate what types of vaccines can stimulate this immune response. Although logical candidates for vaccine components that can stimulate an MHC class I restricted response are live attenuated viruses and DNA vaccines, these materials are generally not allowed in fish for commercial vaccine use due to potential safety issues. In mammals, however, a number of interesting vaccination strategies based on exogenous antigens that stimulate MHC class I restricted cytotoxicity have been described. Several of these strategies are discussed in this review in the context of fish vaccination.

本文言語English
ページ(範囲)437-458
ページ数22
ジャーナルFish and Shellfish Immunology
11
6
DOI
出版ステータスPublished - 08-2001

All Science Journal Classification (ASJC) codes

  • 環境化学
  • 水圏科学

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