Expansion of genes that encode MHC class I molecules in cyprinid fishes

K. Okamura, T. Nakanishi, Y. Kurosawa, K. Hashimoto

研究成果: Article査読

46 被引用数 (Scopus)

抄録

We have analyzed the genomic genes and the mRNA that encode MHC class I molecules in cyprinid fishes, namely, the ginbuna crucian carp (Carassius auratus langsdorfii) and the carp (Cyprinus carpio). The presence of several distinct class I genes was revealed in the genome of cyprinid fishes, and distinct class I genes that are expressed in carp cells were identified. The sequences of the α3 domain of these class I genes are relatively well conserved, whereas the sequences of the respective α1 and α2 domains have diverged from one another. A comparison of the sequences expressed in carp with the sequences of the human classical class I molecules revealed that several amino acids in the peptide-binding region, including those that have been proposed to interact with antigenic peptide termini, are highly conserved. The present study demonstrated a dynamic expansion of the genes that encode MHC class I molecules in teleost fish whose ancestor branched off from the vertebrate line leading to mammals more than 400 million years ago.

本文言語English
ページ(範囲)188-200
ページ数13
ジャーナルJournal of Immunology
151
1
出版ステータスPublished - 01-01-1993

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学

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