Experimental study on platelet activating factor and systemic circulatory failure caused by ischemic liver

T. Fukuoka, Y. Nakajima, H. Nakano, T. Kenmochi, R. Hayashi, S. Suzuki, H. Amemiya

研究成果: Article

抄録

Ischemic hepatic failure is often accompanied by systemic circulatory failure. In hepatic graft failure, this circulatory derangement is reported to be cured by retransplantation. This suggests that ischemic liver might release some substance which causes circulatory depression. In the present study, the role of platelet activating factor (PAF) in systemic circulatory failure after liver ischemia was investigated. Partial hepatic ischemia was induced in ten dogs by clamping the afferent vessels to almost 70% of the liver for 60 minutes, and non-ischemic lobes were resected after declamping. Five were pretreated with 3 mg/kg of PAF antagonist (CV6209) i.v. (PAF antagonist group), and the others were pretreated with saline (control group). The mean arterial pressure markedly decreased after declamping in control group (89 +/- 25mmHg 25 min after declamping), but it did not fall in PAF antagonist group (155 +/- 221mmHg). Three died from either shock or hepatic failure within a week in control group, but none died in PAF antagonist group. In conclusion, ischemic liver was suggested to release PAF and depress systemic circulation. And a PAF antagonist was expected to be an effective drug for the circulatory derangement caused by ischemic liver.

元の言語English
ページ(範囲)1474-1480
ページ数7
ジャーナルNippon Geka Gakkai zasshi
93
発行部数12
出版物ステータスPublished - 12-1992

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Platelet Activating Factor
Shock
Liver
Liver Failure
Control Groups
Ischemia
Constriction
Arterial Pressure
Dogs
Transplants
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Fukuoka, T., Nakajima, Y., Nakano, H., Kenmochi, T., Hayashi, R., Suzuki, S., & Amemiya, H. (1992). Experimental study on platelet activating factor and systemic circulatory failure caused by ischemic liver. Nippon Geka Gakkai zasshi, 93(12), 1474-1480.
Fukuoka, T. ; Nakajima, Y. ; Nakano, H. ; Kenmochi, T. ; Hayashi, R. ; Suzuki, S. ; Amemiya, H. / Experimental study on platelet activating factor and systemic circulatory failure caused by ischemic liver. :: Nippon Geka Gakkai zasshi. 1992 ; 巻 93, 番号 12. pp. 1474-1480.
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abstract = "Ischemic hepatic failure is often accompanied by systemic circulatory failure. In hepatic graft failure, this circulatory derangement is reported to be cured by retransplantation. This suggests that ischemic liver might release some substance which causes circulatory depression. In the present study, the role of platelet activating factor (PAF) in systemic circulatory failure after liver ischemia was investigated. Partial hepatic ischemia was induced in ten dogs by clamping the afferent vessels to almost 70{\%} of the liver for 60 minutes, and non-ischemic lobes were resected after declamping. Five were pretreated with 3 mg/kg of PAF antagonist (CV6209) i.v. (PAF antagonist group), and the others were pretreated with saline (control group). The mean arterial pressure markedly decreased after declamping in control group (89 +/- 25mmHg 25 min after declamping), but it did not fall in PAF antagonist group (155 +/- 221mmHg). Three died from either shock or hepatic failure within a week in control group, but none died in PAF antagonist group. In conclusion, ischemic liver was suggested to release PAF and depress systemic circulation. And a PAF antagonist was expected to be an effective drug for the circulatory derangement caused by ischemic liver.",
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Fukuoka, T, Nakajima, Y, Nakano, H, Kenmochi, T, Hayashi, R, Suzuki, S & Amemiya, H 1992, 'Experimental study on platelet activating factor and systemic circulatory failure caused by ischemic liver', Nippon Geka Gakkai zasshi, 巻. 93, 番号 12, pp. 1474-1480.

Experimental study on platelet activating factor and systemic circulatory failure caused by ischemic liver. / Fukuoka, T.; Nakajima, Y.; Nakano, H.; Kenmochi, T.; Hayashi, R.; Suzuki, S.; Amemiya, H.

:: Nippon Geka Gakkai zasshi, 巻 93, 番号 12, 12.1992, p. 1474-1480.

研究成果: Article

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T1 - Experimental study on platelet activating factor and systemic circulatory failure caused by ischemic liver

AU - Fukuoka, T.

AU - Nakajima, Y.

AU - Nakano, H.

AU - Kenmochi, T.

AU - Hayashi, R.

AU - Suzuki, S.

AU - Amemiya, H.

PY - 1992/12

Y1 - 1992/12

N2 - Ischemic hepatic failure is often accompanied by systemic circulatory failure. In hepatic graft failure, this circulatory derangement is reported to be cured by retransplantation. This suggests that ischemic liver might release some substance which causes circulatory depression. In the present study, the role of platelet activating factor (PAF) in systemic circulatory failure after liver ischemia was investigated. Partial hepatic ischemia was induced in ten dogs by clamping the afferent vessels to almost 70% of the liver for 60 minutes, and non-ischemic lobes were resected after declamping. Five were pretreated with 3 mg/kg of PAF antagonist (CV6209) i.v. (PAF antagonist group), and the others were pretreated with saline (control group). The mean arterial pressure markedly decreased after declamping in control group (89 +/- 25mmHg 25 min after declamping), but it did not fall in PAF antagonist group (155 +/- 221mmHg). Three died from either shock or hepatic failure within a week in control group, but none died in PAF antagonist group. In conclusion, ischemic liver was suggested to release PAF and depress systemic circulation. And a PAF antagonist was expected to be an effective drug for the circulatory derangement caused by ischemic liver.

AB - Ischemic hepatic failure is often accompanied by systemic circulatory failure. In hepatic graft failure, this circulatory derangement is reported to be cured by retransplantation. This suggests that ischemic liver might release some substance which causes circulatory depression. In the present study, the role of platelet activating factor (PAF) in systemic circulatory failure after liver ischemia was investigated. Partial hepatic ischemia was induced in ten dogs by clamping the afferent vessels to almost 70% of the liver for 60 minutes, and non-ischemic lobes were resected after declamping. Five were pretreated with 3 mg/kg of PAF antagonist (CV6209) i.v. (PAF antagonist group), and the others were pretreated with saline (control group). The mean arterial pressure markedly decreased after declamping in control group (89 +/- 25mmHg 25 min after declamping), but it did not fall in PAF antagonist group (155 +/- 221mmHg). Three died from either shock or hepatic failure within a week in control group, but none died in PAF antagonist group. In conclusion, ischemic liver was suggested to release PAF and depress systemic circulation. And a PAF antagonist was expected to be an effective drug for the circulatory derangement caused by ischemic liver.

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