Expression and functional characterization of the system L amino acid transporter in KB human oral epidermoid carcinoma cells

Jung Hoon Yoon; Youn Bae Kim; Myong Soo Kim; Joo Cheol Park; Joong Ki Kook; Hae Man Jung; Saeng Gon Kim; Hoon Yoo; Yeong Mu Ko; Sang Ho Lee; Bong Young Kim; Hong Sung Chun; Yoshikatsu Kanai; Hitoshi Endou; Do Kyung Kim

doi:10.1016/j.canlet.2003.10.009

Expression and functional characterization of the system L amino acid transporter in KB human oral epidermoid carcinoma cells

Jung Hoon Yoon
, Youn Bae Kim
, Myong Soo Kim
, Joo Cheol Park
, Joong Ki Kook
, Hae Man Jung
, Saeng Gon Kim
, Hoon Yoo
, Yeong Mu Ko
, Sang Ho Lee
, Bong Young Kim
, Hong Sung Chun
, Yoshikatsu Kanai
, Hitoshi Endou
, Do Kyung Kim

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

29 被引用数 (Scopus)

抄録

We have examined the expression and function of system L amino acid transporter in KB human oral epidermoid carcinoma cells. The KB cells express L-type amino acid transporter 1 (LAT1) in plasma membrane, but not L-type amino acid transporter 2 (LAT2). The [¹⁴C]L-leucine uptake by KB cells is inhibited by system L selective inhibitor BCH. The majority of [ ¹⁴C]L-leucine uptake is, therefore, mediated by LAT1. These results suggest that the transport of neutral amino acids including several essential amino acids into the KB cells mediated by LAT1 and the specific inhibition of LAT1 in oral cancer cells will be a new rationale for anti-cancer therapy.

本文言語	英語
ページ（範囲）	215-226
ページ数	12
ジャーナル	Cancer Letters
巻	205
号	2
DOI	https://doi.org/10.1016/j.canlet.2003.10.009
出版ステータス	出版済み - 18-03-2004
外部発表	はい

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All Science Journal Classification (ASJC) codes

腫瘍学
癌研究

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10.1016/j.canlet.2003.10.009

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引用スタイル

Yoon, J. H., Kim, Y. B., Kim, M. S., Park, J. C., Kook, J. K., Jung, H. M., Kim, S. G., Yoo, H., Ko, Y. M., Lee, S. H., Kim, B. Y., Chun, H. S., Kanai, Y., Endou, H., & Kim, D. K. (2004). Expression and functional characterization of the system L amino acid transporter in KB human oral epidermoid carcinoma cells. Cancer Letters, 205(2), 215-226. https://doi.org/10.1016/j.canlet.2003.10.009

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title = "Expression and functional characterization of the system L amino acid transporter in KB human oral epidermoid carcinoma cells",

abstract = "We have examined the expression and function of system L amino acid transporter in KB human oral epidermoid carcinoma cells. The KB cells express L-type amino acid transporter 1 (LAT1) in plasma membrane, but not L-type amino acid transporter 2 (LAT2). The [14C]L-leucine uptake by KB cells is inhibited by system L selective inhibitor BCH. The majority of [ 14C]L-leucine uptake is, therefore, mediated by LAT1. These results suggest that the transport of neutral amino acids including several essential amino acids into the KB cells mediated by LAT1 and the specific inhibition of LAT1 in oral cancer cells will be a new rationale for anti-cancer therapy.",

keywords = "Anti-cancer therapy, Essential amino acids, KB human oral epidermoid carcinoma cells, L-Type amino acid transporter",

author = "Yoon, \{Jung Hoon\} and Kim, \{Youn Bae\} and Kim, \{Myong Soo\} and Park, \{Joo Cheol\} and Kook, \{Joong Ki\} and Jung, \{Hae Man\} and Kim, \{Saeng Gon\} and Hoon Yoo and Ko, \{Yeong Mu\} and Lee, \{Sang Ho\} and Kim, \{Bong Young\} and Chun, \{Hong Sung\} and Yoshikatsu Kanai and Hitoshi Endou and Kim, \{Do Kyung\}",

year = "2004",

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doi = "10.1016/j.canlet.2003.10.009",

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journal = "Cancer Letters",

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T1 - Expression and functional characterization of the system L amino acid transporter in KB human oral epidermoid carcinoma cells

AU - Yoon, Jung Hoon

AU - Kim, Youn Bae

AU - Kim, Myong Soo

AU - Park, Joo Cheol

AU - Kook, Joong Ki

AU - Jung, Hae Man

AU - Kim, Saeng Gon

AU - Yoo, Hoon

AU - Ko, Yeong Mu

AU - Lee, Sang Ho

AU - Kim, Bong Young

AU - Chun, Hong Sung

AU - Kanai, Yoshikatsu

AU - Endou, Hitoshi

AU - Kim, Do Kyung

PY - 2004/3/18

Y1 - 2004/3/18

N2 - We have examined the expression and function of system L amino acid transporter in KB human oral epidermoid carcinoma cells. The KB cells express L-type amino acid transporter 1 (LAT1) in plasma membrane, but not L-type amino acid transporter 2 (LAT2). The [14C]L-leucine uptake by KB cells is inhibited by system L selective inhibitor BCH. The majority of [ 14C]L-leucine uptake is, therefore, mediated by LAT1. These results suggest that the transport of neutral amino acids including several essential amino acids into the KB cells mediated by LAT1 and the specific inhibition of LAT1 in oral cancer cells will be a new rationale for anti-cancer therapy.

AB - We have examined the expression and function of system L amino acid transporter in KB human oral epidermoid carcinoma cells. The KB cells express L-type amino acid transporter 1 (LAT1) in plasma membrane, but not L-type amino acid transporter 2 (LAT2). The [14C]L-leucine uptake by KB cells is inhibited by system L selective inhibitor BCH. The majority of [ 14C]L-leucine uptake is, therefore, mediated by LAT1. These results suggest that the transport of neutral amino acids including several essential amino acids into the KB cells mediated by LAT1 and the specific inhibition of LAT1 in oral cancer cells will be a new rationale for anti-cancer therapy.

KW - Anti-cancer therapy

KW - Essential amino acids

KW - KB human oral epidermoid carcinoma cells

KW - L-Type amino acid transporter

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DO - 10.1016/j.canlet.2003.10.009

M3 - Article

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AN - SCOPUS:10744221316

SN - 0304-3835

VL - 205

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EP - 226

JO - Cancer Letters

JF - Cancer Letters

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