Expression level of enzymes related to in situ estrogen synthesis and clinicopathological parameters in breast cancer patients

Masayo Suzuki, Hiroyuki Ishida, Yukimasa Shiotsu, Taisuke Nakata, Shiro Akinaga, Shigemitsu Takashima, Toshiaki Utsumi, Toshiaki Saeki, Nobuhiro Harada

研究成果: Article査読

28 被引用数 (Scopus)

抄録

In order to evaluate the importance of estrogen production in tumor and surrounding tissues, we measured mRNA expression levels of 5 enzymes participating to estrogen synthesis in situ and 4 breast cancer-related proteins in 27 pairs of tumor and non-malignant tissues. Steroid sulfatase (STS) mRNA was more frequently detected in tumor tissues rather than in their non-malignant counterparts. Estrogen sulfotransferase (EST) was constantly expressed with high level not only in tumor tissues but also in their surrounding non-malignant counterparts. In contrast, mRNA expression levels of aromatase, and 17β-hydroxysteroid dehydrogenase type I and II were relatively low and detected only in small proportion of the patients. We also measured the mRNA expression levels of the same nine genes in tumor tissues of 197 breast cancer patients, and analyzed relationship between the mRNA expression level and the clinicopathological parameters. The mRNA expression levels of STS, aromatase and erbB2 in tumor tissues increased as breast cancer progressed. The tumoral mRNA expression levels of STS, estrogen receptor β, and erbB2 in patients with recurrence were higher than those in patients without recurrence. Upregulation of STS expression plays an important role in tumor progression of human breast cancer and is considered to be responsible for estrogen production in tumor and surrounding tissues.

本文言語English
ページ(範囲)195-201
ページ数7
ジャーナルJournal of Steroid Biochemistry and Molecular Biology
113
3-5
DOI
出版ステータスPublished - 02-2009

All Science Journal Classification (ASJC) codes

  • 内分泌学、糖尿病および代謝内科学
  • 生化学
  • 分子医療
  • 分子生物学
  • 内分泌学
  • 臨床生化学
  • 細胞生物学

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