TY - JOUR
T1 - Expression of cancer cachexia-related factors in human cancer xenografts
T2 - An immunohistochemical analysis
AU - Kamoshida, Shingo
AU - Watanabe, Kana
AU - Suzuki, Mai
AU - Mizutani, Yasuyoshi
AU - Sakamoto, Kazuki
AU - Sugimoto, Yoshikazu
AU - Oka, Toshinori
AU - Fukushima, Masakazu
AU - Tsutsumi, Yutaka
PY - 2007/1/10
Y1 - 2007/1/10
N2 - We immunohistochemically evaluated the involvement of five cancer cachexia-related factors, including leukemia-inhibitory factor (LIF), zinc-α2-glycoprotein (ZAG), interleukin 6 (IL-6), proteolysis-inducing factor (PIF) and tumor necrosis factor α (TNF α) in causing cancer cachexia. Twenty-six xenografts implanted into mice were examined for the expression of the cancer cachexia-related factors, in relation to the body weight loss of the hosts. Five xenografts were categorized in the cachectic group, and the remaining 21 xenografts belonged to the non-cachectic group. LIF was extensively expressed in both the cachectic and non-cachectic groups. ZAG and IL-6 were expressed in one of the cachectic and some non-cachectic xenografts. PIF and TNF α were detected in one and two non-cachectic xenografts, respectively, but in none of the cachectic ones. Any of five factors examined were not conclusive for causing cancer cachexia in the murine xenograft model. Further analysis is needed in order to elucidate the mechanisms responsible for cancer cachexia.
AB - We immunohistochemically evaluated the involvement of five cancer cachexia-related factors, including leukemia-inhibitory factor (LIF), zinc-α2-glycoprotein (ZAG), interleukin 6 (IL-6), proteolysis-inducing factor (PIF) and tumor necrosis factor α (TNF α) in causing cancer cachexia. Twenty-six xenografts implanted into mice were examined for the expression of the cancer cachexia-related factors, in relation to the body weight loss of the hosts. Five xenografts were categorized in the cachectic group, and the remaining 21 xenografts belonged to the non-cachectic group. LIF was extensively expressed in both the cachectic and non-cachectic groups. ZAG and IL-6 were expressed in one of the cachectic and some non-cachectic xenografts. PIF and TNF α were detected in one and two non-cachectic xenografts, respectively, but in none of the cachectic ones. Any of five factors examined were not conclusive for causing cancer cachexia in the murine xenograft model. Further analysis is needed in order to elucidate the mechanisms responsible for cancer cachexia.
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U2 - 10.2220/biomedres.27.275
DO - 10.2220/biomedres.27.275
M3 - Article
C2 - 17213683
AN - SCOPUS:33846277628
SN - 0388-6107
VL - 27
SP - 275
EP - 281
JO - Biomedical Research
JF - Biomedical Research
IS - 6
ER -
