Expression of CD44 splicing isoforms in lung cancers: Dominant expression of CD44v8-10 in non-small cell lung carcinomas

J. I.Ichiro Sasaki; Kenneth K. Tanabe; Kazuhisa Takahashi; Isamu Okamoto; Hisao Fujimoto; Mitsuhiro Matsumoto; Moritaka Suga; Masayuki Ando; Hideyuki Saya

doi:10.3892/ijo.12.3.525

Expression of CD44 splicing isoforms in lung cancers: Dominant expression of CD44v8-10 in non-small cell lung carcinomas

J. I.Ichiro Sasaki
, Kenneth K. Tanabe
, Kazuhisa Takahashi
, Isamu Okamoto
, Hisao Fujimoto
, Mitsuhiro Matsumoto
, Moritaka Suga
, Masayuki Ando
, Hideyuki Saya

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

15 被引用数 (Scopus)

抄録

We examined CD44 isoform expression in 138 frozen tissue samples, which included primary lung carcinomas, adjacent non-tumorous lung tissues and benign lung diseases, by both reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemical analyses. CD44v8-10 mRNA and protein were dominantly expressed in non-small cell lung carcinomas (NSCLC), while non-tumorous tissues principally expressed CD44s and small cell lung carcinomas (SCLC) expressed either CD44s or no detectable CD44. These results indicate that CD44v8-10 is the dominant splicing isoform in NSCLC and can be practically utilized as a diagnostic marker and therapeutical target in NSCLC.

本文言語	英語
ページ（範囲）	525-533
ページ数	9
ジャーナル	International journal of oncology
巻	12
号	3
DOI	https://doi.org/10.3892/ijo.12.3.525
出版ステータス	出版済み - 03-1998
外部発表	はい

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All Science Journal Classification (ASJC) codes

腫瘍学
癌研究

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10.3892/ijo.12.3.525

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title = "Expression of CD44 splicing isoforms in lung cancers: Dominant expression of CD44v8-10 in non-small cell lung carcinomas",

abstract = "We examined CD44 isoform expression in 138 frozen tissue samples, which included primary lung carcinomas, adjacent non-tumorous lung tissues and benign lung diseases, by both reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemical analyses. CD44v8-10 mRNA and protein were dominantly expressed in non-small cell lung carcinomas (NSCLC), while non-tumorous tissues principally expressed CD44s and small cell lung carcinomas (SCLC) expressed either CD44s or no detectable CD44. These results indicate that CD44v8-10 is the dominant splicing isoform in NSCLC and can be practically utilized as a diagnostic marker and therapeutical target in NSCLC.",

author = "Sasaki, \{J. I.Ichiro\} and Tanabe, \{Kenneth K.\} and Kazuhisa Takahashi and Isamu Okamoto and Hisao Fujimoto and Mitsuhiro Matsumoto and Moritaka Suga and Masayuki Ando and Hideyuki Saya",

year = "1998",

month = mar,

doi = "10.3892/ijo.12.3.525",

language = "English",

volume = "12",

pages = "525--533",

journal = "International journal of oncology",

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TY - JOUR

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T2 - Dominant expression of CD44v8-10 in non-small cell lung carcinomas

AU - Sasaki, J. I.Ichiro

AU - Tanabe, Kenneth K.

AU - Takahashi, Kazuhisa

AU - Okamoto, Isamu

AU - Fujimoto, Hisao

AU - Matsumoto, Mitsuhiro

AU - Suga, Moritaka

AU - Ando, Masayuki

AU - Saya, Hideyuki

PY - 1998/3

Y1 - 1998/3

N2 - We examined CD44 isoform expression in 138 frozen tissue samples, which included primary lung carcinomas, adjacent non-tumorous lung tissues and benign lung diseases, by both reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemical analyses. CD44v8-10 mRNA and protein were dominantly expressed in non-small cell lung carcinomas (NSCLC), while non-tumorous tissues principally expressed CD44s and small cell lung carcinomas (SCLC) expressed either CD44s or no detectable CD44. These results indicate that CD44v8-10 is the dominant splicing isoform in NSCLC and can be practically utilized as a diagnostic marker and therapeutical target in NSCLC.

AB - We examined CD44 isoform expression in 138 frozen tissue samples, which included primary lung carcinomas, adjacent non-tumorous lung tissues and benign lung diseases, by both reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemical analyses. CD44v8-10 mRNA and protein were dominantly expressed in non-small cell lung carcinomas (NSCLC), while non-tumorous tissues principally expressed CD44s and small cell lung carcinomas (SCLC) expressed either CD44s or no detectable CD44. These results indicate that CD44v8-10 is the dominant splicing isoform in NSCLC and can be practically utilized as a diagnostic marker and therapeutical target in NSCLC.

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DO - 10.3892/ijo.12.3.525

M3 - Article

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AN - SCOPUS:0031882175

SN - 1019-6439

VL - 12

SP - 525

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JO - International journal of oncology

JF - International journal of oncology

IS - 3

ER -

Expression of CD44 splicing isoforms in lung cancers: Dominant expression of CD44v8-10 in non-small cell lung carcinomas

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