Expression of Cdx2 and the phenotype of advanced gastric cancers: Relationship with prognosis

Tsutomu Mizoshita, Tetsuya Tsukamoto, Hayao Nakanishi, Ken Ichi Inada, Naotaka Ogasawara, Takashi Joh, Makoto Itoh, Yoshitaka Yamamura, Masae Tatematsu

研究成果: Article査読

122 被引用数 (Scopus)


Purpose: The clinicopathologic significance of the phenotype and Cdx2 expression has hitherto remained unclear in gastric cancers. In the present study, we therefore examined the correlation between prognosis, phenotype, and Cdx2 expression in advanced cases. Methods: We evaluated 177 advanced gastric carcinomas histologically and phenotypically. The expression of Cdx2 was also assessed by immunohistochemistry. Results: The lesions were phenotypically divided into 32 gastric (G type), 36 gastric and intestinal mixed (GI type), 53 intestinal (I type), and 56 null (N type) types, independent of the histological classification. Cdx2 nuclear staining demonstrated a close relation to intestinal phenotypic expression, not with the histological classification. Kaplan-Meier analysis of Cdx2 expression and the phenotype showed that the Cdx2 positive groups had a significantly better outcome than the negative ones (P = 0.0013), and the patients with GI type cancers had significant better survival than those with N type (P = 0.0052). Conclusions: Our results suggest that Cdx2 is a useful prognostic marker. In addition, advanced gastric cancers with both intestinal and gastric phenotypic expression have a relatively good prognosis. Combined evaluation of gastric and intestinal epithelial cell markers, including Cdx2, is clinically useful to predict outcome in patients with advanced neoplasm of the stomach.

ジャーナルJournal of Cancer Research and Clinical Oncology
出版ステータスPublished - 12-2003

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究


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