Expression of endothelin-1 in macrophages and mast cells in hyperplastic human tonsils

Zhiyuan Li, Yasuharu Niwa, Kazuhito Rokutan, Yutaka Nakaya

研究成果: Article査読

14 被引用数 (Scopus)

抄録

In situ hybridization and immunohistochemical examinations of surgically resected specimens of human hyperplastic tonsils showed that macrophages in the germinal center and mast cells in the parafollicular and interfollicular areas expressed the transcript and protein of endothelin (ET)-1, but not ET-2 and ET-3. The macrophages appeared to be activated, since they possessed significant amounts of inducible nitric oxide synthase. None of these expressions was observed in normal tonsil. Our results suggest that the over-production of ET-1 by macrophages and mast cells may be involved in the pathogenesis of hyperplastic tonsils. Copyright (C) 1999 Federation of European Biochemical Societies.

本文言語English
ページ(範囲)381-384
ページ数4
ジャーナルFEBS Letters
457
3
DOI
出版ステータスPublished - 03-09-1999
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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