TY - JOUR
T1 - Expression of heparin-binding epidermal growth factor-like growth factor in pancreatic adenocarcinoma
AU - Ito, Yasuhiro
AU - Higashiyama, Shigeki
AU - Takeda, Tsutomu
AU - Yamamoto, Yasuko
AU - Wakasa, Ken ichi
AU - Matsuura, Nariaki
PY - 2001
Y1 - 2001
N2 - Background. Previous studies demonstrated that heparin-binding epidermal growth factor-like growth factor (HB-EGF) contributes to carcinogenesis and carcinoma progression. In this study, we investigated its expression in human pancreatic adenocarcinoma. Methods. We immunohistochemically investigated the expression of HB-EGF in 40 cases of pancreatic adenocarcinoma. Results. HB-EGF was only occasionally and faintly expressed in normal and hyperplastic pancreas duct epithelia. In pancreatic adenocarcinoma, 22 (55.0%) of the 40 cases were classified as positive for HB-EGF. Its expression was more frequently observed in cases with a low Ki-67 labeling index, well differentiated, early stage, small size, without lymph node metastasis and low EGF-R expression. Conclusion. These results suggest that HB-EGF mainly plays a role in early phase of the progression of pancreatic adenocarcinoma.
AB - Background. Previous studies demonstrated that heparin-binding epidermal growth factor-like growth factor (HB-EGF) contributes to carcinogenesis and carcinoma progression. In this study, we investigated its expression in human pancreatic adenocarcinoma. Methods. We immunohistochemically investigated the expression of HB-EGF in 40 cases of pancreatic adenocarcinoma. Results. HB-EGF was only occasionally and faintly expressed in normal and hyperplastic pancreas duct epithelia. In pancreatic adenocarcinoma, 22 (55.0%) of the 40 cases were classified as positive for HB-EGF. Its expression was more frequently observed in cases with a low Ki-67 labeling index, well differentiated, early stage, small size, without lymph node metastasis and low EGF-R expression. Conclusion. These results suggest that HB-EGF mainly plays a role in early phase of the progression of pancreatic adenocarcinoma.
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U2 - 10.1385/IJGC:29:1:47
DO - 10.1385/IJGC:29:1:47
M3 - Article
C2 - 11558632
AN - SCOPUS:0034829649
SN - 0169-4197
VL - 29
SP - 47
EP - 52
JO - International Journal of Pancreatology
JF - International Journal of Pancreatology
IS - 1
ER -