Expression of nestin mRNA is a differentiation marker in thyroid tumors

Hiroya Yamada, Toru Takano, Yasuhiro Ito, Fumio Matsuzuka, Akihiro Miya, Kaoru Kobayashi, Hiroshi Yoshida, Mikio Watanabe, Yoshinori Iwatani, Akira Miyauchi

研究成果: Article査読

23 被引用数 (Scopus)

抄録

Nestin is a maker that identifies stem cells in some adult tissues, and its expression is believed to relate to malignancy in cancer cells. In this study, we measured the expression levels of nestin mRNA in various kinds of thyroid tumor by the real-time quantitative reverse transcription-polymerase chain reaction. Unexpectedly, nestin mRNA was detected in almost all differentiated thyroid tumors and normal thyroid tissues, whereas extremely decreased expression was observed in anaplastic carcinomas, which are the most malignant of the thyroid follicular cell-derived tumors. These results suggest that nestin mRNA is a differentiation marker, and its expression does not relate to malignant characteristics in thyroid tumors.

本文言語English
ページ(範囲)61-64
ページ数4
ジャーナルCancer Letters
280
1
DOI
出版ステータスPublished - 18-07-2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

フィンガープリント 「Expression of nestin mRNA is a differentiation marker in thyroid tumors」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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