Expression of protein kinase c isozyme in epidermal langerhans cells of the mouse

Yoh ichi Koyama, Takahisa Hachiya, Masatoshi Hagiwara, Miya Kobayashi, Koji Ohashi, Takeshi Hoshino, Hiroyoshi Hidaka, Tohru Marunouchi

研究成果: Article査読

22 被引用数 (Scopus)

抄録

Protein kinase C (PKC) is encoded by a complex of a gene family, and its multiple isozymes are expressed in various mammalian tissues. We examined whether PKC is expressed in epidermal Langerhans cells (LC) of the mouse by using monoclonal antibodies specific to PKC I, PKC II, and PKC III isozymes (respective products of PKC genes γ, β, and α). Immunohistochemical and immunoblotting studies revealed that LC of adult C57BL/6 mice express PKC II, while PKC I and PKC III were not detected. In keratinocytes, none of the isozymes were detected. These results suggest that PKC II is a novel marker of LC and that it possibly plays a regulatory role in epidermal LC of the mouse in vivo.

本文言語English
ページ(範囲)677-680
ページ数4
ジャーナルJournal of Investigative Dermatology
94
5
DOI
出版ステータスPublished - 05-1990

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学
  • 皮膚病学
  • 細胞生物学

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