Expression of ret finger protein correlates with outcomes in endometrial cancer

Hirohisa Tsukamoto, Takuya Kato, Atsushi Enomoto, Nobuhisa Nakamura, Yohei Shimono, Mayumi Jijiwa, Naoya Asai, Yoshiki Murakumo, Kiyosumi Shibata, Fumitaka Kikkawa, Masahide Takahashi

研究成果: Article査読

24 被引用数 (Scopus)

抄録

Ret finger protein (RFP) is a nuclear protein with transcriptional repressive activity that is highly expressed in a variety of human and rodent tumor cell lines. We examined the expression of RFP in human endometrial cancer and assessed its clinical significance. Formalin-fixed, paraffin-embedded sections from endometrial cancer tissues were immunostained with the RFP antibody, and the staining intensity was evaluated. The clinicopathological factors examined were age, International Federation of Gynecology and Obstetrics stage, tumor grade, myometrial invasion, and pelvic lymph node metastasis. Overall survival (OS) and progression-free survival (PFS) were evaluated using the Kaplan-Meier method, and multivariate analysis was performed using the Cox proportional hazard analysis. Of the 119 cancer tissues, 57 (47.9%) cases were positive for RFP immunoreactivity. RFP expression was not associated with any of the clinicopathological parameters examined. However, positive RFP expression significantly predicted poorer OS and PFS compared with negative expression (OS, P = 0.0011; PFS, P < 0.0001). In the multivariate analyses, positive RFP expression was an independent prognostic factor for survival in this study. RFP knockdown significantly impaired cancer cell migration and invasion in vitro with concomitant decreases of integrins β1 and α2. Positive RFP expression is a predictive marker for an unfavorable clinical outcome in patients with endometrial cancer. (Cancer Sci 2009; 100: 1895-1901).

本文言語English
ページ(範囲)1895-1901
ページ数7
ジャーナルCancer science
100
10
DOI
出版ステータスPublished - 10-2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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