TY - JOUR
T1 - Expression of SOX9 is related to prognosis in patients with oesophageal squamous cell carcinoma
AU - Higo, Naotomo
AU - Okumura, Hiroshi
AU - Uchikado, Yasuto
AU - Omoto, Itaru
AU - Sasaki, Ken
AU - Kita, Yoshiaki
AU - Ryosuke, Desaki
AU - Noda, Masahiro
AU - Owaki, Tetsuhiro
AU - Ishigami, Sumiya
AU - Natsugoe, Shoji
N1 - Publisher Copyright:
© 2018 Universidade Federal Rural do Semi-Arido. All Rights Reserved.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Background: Sex-determining region Y-box 9 (SOX9) is an important transcription factor for the development and differentiation of cells and their organization. In the present study, the clinical significance of SOX9 expression in oesophageal squamous cell carcinoma was examined. Materials and Methods: SOX9 expression in surgical specimens of primary tumours were immunohistochemically investigated in 175 patients with oesophageal squamous cell carcinomas. Results: SOX9 was expressed (moderately or strongly) in 62.9% of samples. Expression of SOX9 was significantly positively correlated with depth of invasion, advanced stage, lymphatic and venous invasion, and poor prognosis. Univariate analysis showed that depth of invasion, lymph node metastasis, distant metastasis, stage, lymphatic invasion, venous invasion, and SOX9 expression were prognostic factors. Multivariate analysis indicated that depth of invasion and stage were independent prognostic factors, but SOX9 expression was not. Conclusion: SOX9 expression is related to prognosis in patients with oesophageal squamous cell carcinoma, although it is not an independent prognostic factor.
AB - Background: Sex-determining region Y-box 9 (SOX9) is an important transcription factor for the development and differentiation of cells and their organization. In the present study, the clinical significance of SOX9 expression in oesophageal squamous cell carcinoma was examined. Materials and Methods: SOX9 expression in surgical specimens of primary tumours were immunohistochemically investigated in 175 patients with oesophageal squamous cell carcinomas. Results: SOX9 was expressed (moderately or strongly) in 62.9% of samples. Expression of SOX9 was significantly positively correlated with depth of invasion, advanced stage, lymphatic and venous invasion, and poor prognosis. Univariate analysis showed that depth of invasion, lymph node metastasis, distant metastasis, stage, lymphatic invasion, venous invasion, and SOX9 expression were prognostic factors. Multivariate analysis indicated that depth of invasion and stage were independent prognostic factors, but SOX9 expression was not. Conclusion: SOX9 expression is related to prognosis in patients with oesophageal squamous cell carcinoma, although it is not an independent prognostic factor.
KW - Oesophageal cancer
KW - Prognosis
KW - SOX9
UR - https://www.scopus.com/pages/publications/85050009333
UR - https://www.scopus.com/pages/publications/85050009333#tab=citedBy
U2 - 10.21873/invivo.11316
DO - 10.21873/invivo.11316
M3 - Article
C2 - 29936467
AN - SCOPUS:85050009333
SN - 0258-851X
VL - 32
SP - 835
EP - 838
JO - In Vivo
JF - In Vivo
IS - 4
ER -