Expression of the Q8/9d gene by T cells of the mouse

Akihiro Matsuura, Rene Schloss, Fung Win Shen, Jwu Sheng Tung, Stephen W. Hunt, Douglas A. Fisher, Leroy E. Hood, Edward A. Boyse

研究成果: Article

11 引用 (Scopus)

抄録

The Q genes, specifying Qa antigens and situated in the extended part of the major histocompatibility complex (MHC) of the mouse, comprise a subgroup of MHC class I genes whose significance and function are still largely unknown. In screening a cDNA library made from the BALB/c inducer T-cell line Cl.Ly1-T1, we isolated 11 clones representing Q8/9, but none representing Q6 or Q7. Confirmatory evidence is given that the Q8/9 gene originated from fusion of the 5′ region of the Q8 gene with the 3′ region of the Q9 gene at a recombination site or hot spot in the vicinity of intron 4. Contrary to previous impressions that Q8/9 is an inert pseudogene, we find that the Q8/9 gene can be functional and encode a Qa-2,3 antigen. One variety of the 11 Q8/9 clones isolated lacked exon 5, which encodes the transmembrane domain of class I glycoproteins, and thus may account for secretion of a soluble form of Qa-2,3 antigen thought to be released by activated T cells.

元の言語English
ページ(範囲)156-161
ページ数6
ジャーナルImmunogenetics
30
発行部数3
DOI
出版物ステータスPublished - 01-09-1989

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Major Histocompatibility Complex
T-Lymphocytes
Clone Cells
vif Genes
Genes
MHC Class I Genes
Pseudogenes
Gene Fusion
Helper-Inducer T-Lymphocytes
Gene Library
Introns
Genetic Recombination
Exons
Glycoproteins
Antigens
Cell Line
Q surface antigens

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics

これを引用

Matsuura, A., Schloss, R., Shen, F. W., Tung, J. S., Hunt, S. W., Fisher, D. A., ... Boyse, E. A. (1989). Expression of the Q8/9d gene by T cells of the mouse. Immunogenetics, 30(3), 156-161. https://doi.org/10.1007/BF02421200
Matsuura, Akihiro ; Schloss, Rene ; Shen, Fung Win ; Tung, Jwu Sheng ; Hunt, Stephen W. ; Fisher, Douglas A. ; Hood, Leroy E. ; Boyse, Edward A. / Expression of the Q8/9d gene by T cells of the mouse. :: Immunogenetics. 1989 ; 巻 30, 番号 3. pp. 156-161.
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Matsuura, A, Schloss, R, Shen, FW, Tung, JS, Hunt, SW, Fisher, DA, Hood, LE & Boyse, EA 1989, 'Expression of the Q8/9d gene by T cells of the mouse', Immunogenetics, 巻. 30, 番号 3, pp. 156-161. https://doi.org/10.1007/BF02421200

Expression of the Q8/9d gene by T cells of the mouse. / Matsuura, Akihiro; Schloss, Rene; Shen, Fung Win; Tung, Jwu Sheng; Hunt, Stephen W.; Fisher, Douglas A.; Hood, Leroy E.; Boyse, Edward A.

:: Immunogenetics, 巻 30, 番号 3, 01.09.1989, p. 156-161.

研究成果: Article

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Matsuura A, Schloss R, Shen FW, Tung JS, Hunt SW, Fisher DA その他. Expression of the Q8/9d gene by T cells of the mouse. Immunogenetics. 1989 9 1;30(3):156-161. https://doi.org/10.1007/BF02421200