Expression of the Q8/9d gene by T cells of the mouse

Akihiro Matsuura, Rene Schloss, Fung Win Shen, Jwu Sheng Tung, Stephen W. Hunt, Douglas A. Fisher, Leroy E. Hood, Edward A. Boyse

研究成果: Article査読

11 被引用数 (Scopus)

抄録

The Q genes, specifying Qa antigens and situated in the extended part of the major histocompatibility complex (MHC) of the mouse, comprise a subgroup of MHC class I genes whose significance and function are still largely unknown. In screening a cDNA library made from the BALB/c inducer T-cell line Cl.Ly1-T1, we isolated 11 clones representing Q8/9, but none representing Q6 or Q7. Confirmatory evidence is given that the Q8/9 gene originated from fusion of the 5′ region of the Q8 gene with the 3′ region of the Q9 gene at a recombination site or hot spot in the vicinity of intron 4. Contrary to previous impressions that Q8/9 is an inert pseudogene, we find that the Q8/9 gene can be functional and encode a Qa-2,3 antigen. One variety of the 11 Q8/9 clones isolated lacked exon 5, which encodes the transmembrane domain of class I glycoproteins, and thus may account for secretion of a soluble form of Qa-2,3 antigen thought to be released by activated T cells.

本文言語English
ページ(範囲)156-161
ページ数6
ジャーナルImmunogenetics
30
3
DOI
出版ステータスPublished - 09-1989
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫学
  • 遺伝学

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