抄録
The Q genes, specifying Qa antigens and situated in the extended part of the major histocompatibility complex (MHC) of the mouse, comprise a subgroup of MHC class I genes whose significance and function are still largely unknown. In screening a cDNA library made from the BALB/c inducer T-cell line Cl.Ly1-T1, we isolated 11 clones representing Q8/9, but none representing Q6 or Q7. Confirmatory evidence is given that the Q8/9 gene originated from fusion of the 5′ region of the Q8 gene with the 3′ region of the Q9 gene at a recombination site or hot spot in the vicinity of intron 4. Contrary to previous impressions that Q8/9 is an inert pseudogene, we find that the Q8/9 gene can be functional and encode a Qa-2,3 antigen. One variety of the 11 Q8/9 clones isolated lacked exon 5, which encodes the transmembrane domain of class I glycoproteins, and thus may account for secretion of a soluble form of Qa-2,3 antigen thought to be released by activated T cells.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 156-161 |
| ページ数 | 6 |
| ジャーナル | Immunogenetics |
| 巻 | 30 |
| 発行部数 | 3 |
| DOI | |
| 出版物ステータス | Published - 01-09-1989 |
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All Science Journal Classification (ASJC) codes
- Immunology
- Genetics
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Expression of the Q8/9d gene by T cells of the mouse. / Matsuura, Akihiro; Schloss, Rene; Shen, Fung Win; Tung, Jwu Sheng; Hunt, Stephen W.; Fisher, Douglas A.; Hood, Leroy E.; Boyse, Edward A.
：: Immunogenetics, 巻 30, 番号 3, 01.09.1989, p. 156-161.研究成果: Article
TY - JOUR
T1 - Expression of the Q8/9d gene by T cells of the mouse
AU - Matsuura, Akihiro
AU - Schloss, Rene
AU - Shen, Fung Win
AU - Tung, Jwu Sheng
AU - Hunt, Stephen W.
AU - Fisher, Douglas A.
AU - Hood, Leroy E.
AU - Boyse, Edward A.
PY - 1989/9/1
Y1 - 1989/9/1
N2 - The Q genes, specifying Qa antigens and situated in the extended part of the major histocompatibility complex (MHC) of the mouse, comprise a subgroup of MHC class I genes whose significance and function are still largely unknown. In screening a cDNA library made from the BALB/c inducer T-cell line Cl.Ly1-T1, we isolated 11 clones representing Q8/9, but none representing Q6 or Q7. Confirmatory evidence is given that the Q8/9 gene originated from fusion of the 5′ region of the Q8 gene with the 3′ region of the Q9 gene at a recombination site or hot spot in the vicinity of intron 4. Contrary to previous impressions that Q8/9 is an inert pseudogene, we find that the Q8/9 gene can be functional and encode a Qa-2,3 antigen. One variety of the 11 Q8/9 clones isolated lacked exon 5, which encodes the transmembrane domain of class I glycoproteins, and thus may account for secretion of a soluble form of Qa-2,3 antigen thought to be released by activated T cells.
AB - The Q genes, specifying Qa antigens and situated in the extended part of the major histocompatibility complex (MHC) of the mouse, comprise a subgroup of MHC class I genes whose significance and function are still largely unknown. In screening a cDNA library made from the BALB/c inducer T-cell line Cl.Ly1-T1, we isolated 11 clones representing Q8/9, but none representing Q6 or Q7. Confirmatory evidence is given that the Q8/9 gene originated from fusion of the 5′ region of the Q8 gene with the 3′ region of the Q9 gene at a recombination site or hot spot in the vicinity of intron 4. Contrary to previous impressions that Q8/9 is an inert pseudogene, we find that the Q8/9 gene can be functional and encode a Qa-2,3 antigen. One variety of the 11 Q8/9 clones isolated lacked exon 5, which encodes the transmembrane domain of class I glycoproteins, and thus may account for secretion of a soluble form of Qa-2,3 antigen thought to be released by activated T cells.
UR - http://www.scopus.com/inward/record.url?scp=0024474076&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024474076&partnerID=8YFLogxK
U2 - 10.1007/BF02421200
DO - 10.1007/BF02421200
M3 - Article
C2 - 2789189
AN - SCOPUS:0024474076
VL - 30
SP - 156
EP - 161
JO - Immunogenetics
JF - Immunogenetics
SN - 0093-7711
IS - 3
ER -