Extended-spectrum AmpC cephalosporinase in Acinetobacter baumannii: ADC-56 confers resistance to cefepime

Guo Bao Tian, Jennifer M. Adams-Haduch, Magdalena Taracila, Robert A. Bonomo, Hong Ning Wang, Yohei Doi

研究成果: Article査読

47 被引用数 (Scopus)

抄録

ADC-56, a novel extended-spectrum AmpC (ESAC) β-lactamase, was identified in an Acinetobacter baumannii clinical isolate. ADC-56 possessed an R148Q change compared with its putative progenitor, ADC-30, which enabled it to hydrolyze cefepime. Molecular modeling suggested that R148 interacted with Q267, E272, and I291 through a hydrogen bond network which constrained the H-10 helix. This permitted cefepime to undergo conformational changes in the active site, with the carboxyl interacting with R340, likely allowing for better binding and turnover.

本文言語English
ページ(範囲)4922-4925
ページ数4
ジャーナルAntimicrobial agents and chemotherapy
55
10
DOI
出版ステータスPublished - 10-2011
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬理学(医学)
  • 感染症

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