Extraction of biomolecular signals controlling complex behavior of biological cells

Yuichi Sakumura, Katsuyuki Kunida

研究成果: Conference contribution

抄録

Cell deformation and migration are one of the important biological functions related to various biological phenomena. In this study, using the time-series data of cell morphological changes (protrusion and retraction of cell leading edge) and activities of regulatory molecules, we propose a novel method of data analysis for extracting molecular activity patterns corresponding to specific morphological changes based on the reverse correlation analysis. This method was applied to the time-series data of the three representative regulatory molecules measured from cultured cells. We extracted the dynamical molecular activities for four types of the morphological change; constant protrusion and retraction, and transient protrusion and retraction. Although it has been difficult to link cell movement and biochemical findings, we confirmed that our results are consistent with previous findings in the field of biochemistry.

本文言語English
ホスト出版物のタイトル2019 Asia-Pacific Signal and Information Processing Association Annual Summit and Conference, APSIPA ASC 2019
出版社Institute of Electrical and Electronics Engineers Inc.
ページ731-735
ページ数5
ISBN(電子版)9781728132488
DOI
出版ステータスPublished - 11-2019
外部発表はい
イベント2019 Asia-Pacific Signal and Information Processing Association Annual Summit and Conference, APSIPA ASC 2019 - Lanzhou, China
継続期間: 18-11-201921-11-2019

出版物シリーズ

名前2019 Asia-Pacific Signal and Information Processing Association Annual Summit and Conference, APSIPA ASC 2019

Conference

Conference2019 Asia-Pacific Signal and Information Processing Association Annual Summit and Conference, APSIPA ASC 2019
国/地域China
CityLanzhou
Period18-11-1921-11-19

All Science Journal Classification (ASJC) codes

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