TY - JOUR
T1 - Extranodal NK/T-cell lymphoma, nasal type accompanied by PR3-ANCA-associated glomerulonephritis
AU - Tamoto, Yuta
AU - Ishida, Ryo
AU - Shiogama, Kazuya
AU - Kado, Hiroshi
AU - Kamezaki, Michitsugu
AU - Chinen, Yoshiaki
AU - Matsumoto, Yosuke
AU - Kusaba, Tetsuro
AU - Konishi, Eiichi
AU - Tsutsumi, Yutaka
AU - Tamagaki, Keiichi
N1 - Publisher Copyright:
© 2017 The Japanese Society of Internal Medicine.
PY - 2017
Y1 - 2017
N2 - A 62-year-old man exhibiting nasal obstruction and glomerulonephritis with proteinase 3-antineutrophil cytoplasmic antibodies (PR3-ANCAs) was diagnosed with extranodal NK/T-cell lymphoma, nasal type (ENKL) with infiltration of neutrophils with apoptosis. Chemoradiotherapy reduced the tumor, improved the renal function, and decreased the PR3-ANCA levels. ANCA-positivity is observed in immunoinsufficient diseases, in which neutrophils lead to apoptosis and translocate intracellular granules, such as PR3, to the cell surface, triggering the production of ANCAs. In our case, the PR3-ANCA production was derived from the expression of PR3 on the cell surface of apoptotic neutrophils. This is the first report on ENKL describing the mechanism of ANCA development.
AB - A 62-year-old man exhibiting nasal obstruction and glomerulonephritis with proteinase 3-antineutrophil cytoplasmic antibodies (PR3-ANCAs) was diagnosed with extranodal NK/T-cell lymphoma, nasal type (ENKL) with infiltration of neutrophils with apoptosis. Chemoradiotherapy reduced the tumor, improved the renal function, and decreased the PR3-ANCA levels. ANCA-positivity is observed in immunoinsufficient diseases, in which neutrophils lead to apoptosis and translocate intracellular granules, such as PR3, to the cell surface, triggering the production of ANCAs. In our case, the PR3-ANCA production was derived from the expression of PR3 on the cell surface of apoptotic neutrophils. This is the first report on ENKL describing the mechanism of ANCA development.
KW - Apoptosis
KW - Extranodal NK/T-cell lymphoma
KW - Nasal type
KW - Neutrophil
KW - Proteinase 3 antineutrophil cytoplasmic antibodies
UR - https://www.scopus.com/pages/publications/85026760205
UR - https://www.scopus.com/pages/publications/85026760205#tab=citedBy
U2 - 10.2169/internalmedicine.56.8365
DO - 10.2169/internalmedicine.56.8365
M3 - Article
C2 - 28768972
AN - SCOPUS:85026760205
SN - 0918-2918
VL - 56
SP - 2007
EP - 2012
JO - Internal Medicine
JF - Internal Medicine
IS - 15
ER -