Extremely poor postrecurrence oncological outcome for patients with recurrent mucinous ovarian cancer

Hiroaki Kajiyama, Mika Mizuno, Kiyosumi Shibata, Michiyasu Kawai, Tetsuro Nagasaka, Fumitaka Kikkawa

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Background: This study was conducted to assess the long-term clinical outcome for patients with recurrent mucinous epithelial ovarian cancer (RmOC) in comparison with recurrent serous epithelial ovarian cancer (RsOC). Methods: Three hundred and eighty-four patients with recurrent ovarian cancer, including 340 RsOC and 44 RmOC patients, were analyzed in this study. The pathological slides were evaluated under central pathological review. The prognostic significance of clinicopathological factors was evaluated employing both uni- and multivariable analysis. Results: The 3- and 5-year postrecurrence survival (PRS) rates of patients with RmOC were 17.3, and 6.9 %, respectively. In contrast, those of patients with RsOC were 29.8 and 18.8 %, respectively. The PRS of patients with RmOC was significantly poorer than that of patients with RsOC (PRS: P = 0.0006). Moreover, either in the presence or absence of a residual tumor (RT) at initial surgery, the PRS of patients with RmOC was markedly poorer than that of patients with RsOC [RT (-): P < 0.0001: RT (+): P = 0.0912]. In multivariable analysis, a mucinous histology predicted a significantly poorer PRS (RmOC vs. RsOC: hazard ratio (HR) 2.080, 95 % confidence interval (CI) 1.434-3.016, P = 0.0001). Confining analysis to deceased patients (N = 302), the proportion of RmOC patients who died within 12 months following recurrence was markedly higher than that of RsOC [RmOC 69.2 %, RsOC: 41.1 % (P < 0.0001)]. Conclusions: The clinical outcome after recurrence in patients with RmOC was extremely poor. This confirms that RmOC should be considered a different entity from other epithelial ovarian cancers.

本文言語English
ページ(範囲)121-126
ページ数6
ジャーナルInternational Journal of Clinical Oncology
19
1
DOI
出版ステータスPublished - 02-2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • 外科
  • 血液学
  • 腫瘍学

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