Factors Associated with Daptomycin-Induced Eosinophilic Pneumonia

Kazuhiro Ishikawa, Takahiro Matsuo, Yasumasa Tsuda, Mahbubur Rahman, Yuki Uehara, Nobuyoshi Mori

研究成果: ジャーナルへの寄稿学術論文査読

1 被引用数 (Scopus)

抄録

The risk factors for eosinophilic pneumonia (EP) remain unclear. We investigate the characteristics of patients with daptomycin (DAP)-induced EP and conducted a retrospective observational study. A total of 450 patients aged ≥ 18 years who received DAP (25 DAP with EP, 425 DAP without EP) were included. The median duration from the first DAP administration to EP onset was 18.0 days. Definite, probable, and possible DAP-induced EP were diagnosed in 0, 9, and 16 patients, respectively. The median age (DAP with EP, 72.0 years; DAP without EP, 64.0 years), DAP dosage/body weight (BW) (9.00 vs. 7.50 mg/kg), blood eosinophil count (cells/µL) (419 vs. 96), and the percentage of hemodialyzed patients (40.0% vs. 13.4%) were significantly higher in patients with EP than in patients without EP in the univariate analysis. In separate multivariate logistic regression analyses, age (odds ratio (OR), 1.03; 95% confidence interval (CI), 1.00–1.05), DAP dosage/BW (OR, 1.61; 95% CI, 1.25–2.07), and hemodialysis (OR, 4.42; 95% CI, 1.86–10.5) were significantly associated with DAP-induced EP. Clinicians may need to consider the potential factors associated with EP, especially in older patients, patients on hemodialysis, or patients who receive > 9.00 mg/kg of DAP.

本文言語英語
論文番号254
ジャーナルAntibiotics
11
2
DOI
出版ステータス出版済み - 02-2022
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学、毒性学および薬学一般
  • 微生物学(医療)
  • 感染症
  • 薬理学(医学)
  • 生化学
  • 微生物学

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