Factors contributing to sleep disturbance and hypnotic drug use in hemodialysis patients

Akiko Noda, Shigeru Nakai, Taro Soga, Tatsuki Sugiura, Norihisa Iwayama, Kenji Maeda, Misaho Atarashi, Fumihiko Yasuma, Norio Ozaki, Mitsuhiro Yokota, Yasuo Koike

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Objective: Sleep disturbance and the use of hypnotic medications are common in patients on hemodialysis. Factors that contribute to sleep disturbance and the use of hypnotic medications in hemodialysis patients were investigated. Methods: With the use of a questionnaire-based survey, we examined the prevalence of symptoms that reflect sleep disorders such as insomnia, restless legs syndrome (RLS), and snoring and use of hypnotic medications in 252 hemodialysis patients. Results: The overall prevalence of insomnia was 59.1%, with the prevalence of difficulty in initiating sleep (DIS), difficulty in maintaining sleep (DMS), and early morning awakening (EMA) being 47.6, 24.2, and 28.2%, respectively. Daytime sleepiness and habitual snoring were reported by 42.5 and 33.7%, respectively. The prevalence of routine use of hypnotic drugs was 25.8%. Both RLS and age were significantly associated with insomnia [odds ratio (OR), 3.75; p < 0.001, OR, 1.03; p < 0.01]. RLS was a significant factor for DIS, DMS, and EMA (OR, 2.26; p < 0.05, OR, 3.44; p < 0.0005, OR, 4.25; p < 0.0005) and age was a significant factor for DMS and EMA (OR, 1.03; p = 0.053, OR, 1.05; p < 0.005). Both insomnia and snoring were associated with the use of hypnotic drugs (OR, 2.97; p < 0.001, 1.59; p=0.13). Conclusion: Both RLS and sleep-disordered breathing may contribute to sleep disturbance in hemodialysis patients. RLS in particular may be an important factor in insomnia, which in turn is likely responsible for the high prevalence of hypnotic drug use in hemodialysis patients.

本文言語English
ページ(範囲)1273-1278
ページ数6
ジャーナルInternal Medicine
45
22
DOI
出版ステータスPublished - 15-12-2006
外部発表はい

All Science Journal Classification (ASJC) codes

  • 内科学

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