TY - JOUR
T1 - Factors correlating with acoustic radiation force impulse elastography in chronic hepatitis C
AU - Nishikawa, Toru
AU - Hashimoto, Senju
AU - Kawabe, Naoto
AU - Harata, Masao
AU - Nitta, Yoshifumi
AU - Murao, Michihito
AU - Nakano, Takuji
AU - Mizuno, Yuko
AU - Shimazaki, Hiroaki
AU - Kan, Toshiki
AU - Nakaoka, Kazunori
AU - Takagawa, Yuka
AU - Ohki, Masashi
AU - Ichino, Naohiro
AU - Osakabe, Keisuke
AU - Yoshioka, Kentaro
PY - 2014/2/7
Y1 - 2014/2/7
N2 - AIM: To investigate the factors other than fibrosis stage correlating with acoustic radiation force impulse (ARFI) elastograpy in chronic hepatitis C. METHODS: ARFI elastograpy was performed in 108 consecutive patients with chronic hepatitis C who underwent a liver biopsy. The proportion of fibrosis area in the biopsy specimens was measured by computerassisted morphometric image analysis. RESULTS: ARFI correlated significantly with fibrosis stage (β = 0.1865, P < 0.0001) and hyaluronic acid levels (β = 0.0008, P = 0.0039) in all patients by multiple regression analysis. Fibrosis area correlated sigsignificantly with ARFI by Spearman's rank correlation test but not by multiple regression analysis. ARFI correlated significantly with body mass index (BMI) (β = -0.0334, P = 0.0001) in F 0 or F 1, with γ-glutamyltranspeptidase levels (β = 0.0048, P = 0.0012) in F 2, and with fibrosis stage (β = 0.2921, P = 0.0044) and hyaluronic acid levels (β = 0.0012, P = 0.0025) in F 3 or F 4. The ARFI cutoff value was 1.28 m/s for F ≥ 2, 1.44 m/s for F ≥ 3, and 1.73 m/s for F 4. CONCLUSION: ARFI correlated with fibrosis stage and hyaluronic acid but not with inflammation. ARFI was affected by BMI, γ-glutamyltranspeptidase, and hyaluronic acid in each fibrosis stage.
AB - AIM: To investigate the factors other than fibrosis stage correlating with acoustic radiation force impulse (ARFI) elastograpy in chronic hepatitis C. METHODS: ARFI elastograpy was performed in 108 consecutive patients with chronic hepatitis C who underwent a liver biopsy. The proportion of fibrosis area in the biopsy specimens was measured by computerassisted morphometric image analysis. RESULTS: ARFI correlated significantly with fibrosis stage (β = 0.1865, P < 0.0001) and hyaluronic acid levels (β = 0.0008, P = 0.0039) in all patients by multiple regression analysis. Fibrosis area correlated sigsignificantly with ARFI by Spearman's rank correlation test but not by multiple regression analysis. ARFI correlated significantly with body mass index (BMI) (β = -0.0334, P = 0.0001) in F 0 or F 1, with γ-glutamyltranspeptidase levels (β = 0.0048, P = 0.0012) in F 2, and with fibrosis stage (β = 0.2921, P = 0.0044) and hyaluronic acid levels (β = 0.0012, P = 0.0025) in F 3 or F 4. The ARFI cutoff value was 1.28 m/s for F ≥ 2, 1.44 m/s for F ≥ 3, and 1.73 m/s for F 4. CONCLUSION: ARFI correlated with fibrosis stage and hyaluronic acid but not with inflammation. ARFI was affected by BMI, γ-glutamyltranspeptidase, and hyaluronic acid in each fibrosis stage.
KW - Acoustic radiation force impulse
KW - Body mass index
KW - Chronic hepatitis C
KW - Computer-assisted morphometric image analysis
KW - Fibrosis stage
KW - Hyaluronic acid
KW - Liver stiffness measurement
KW - Transient elastography
KW - Velocity of shear wave
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U2 - 10.3748/wjg.v20.i5.1289
DO - 10.3748/wjg.v20.i5.1289
M3 - Article
C2 - 24574802
AN - SCOPUS:84893108406
SN - 1007-9327
VL - 20
SP - 1289
EP - 1297
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 5
ER -
