Factors correlating with acoustic radiation force impulse elastography in chronic hepatitis C

Toru Nishikawa, Senju Hashimoto, Naoto Kawabe, Masao Harata, Yoshifumi Nitta, Michihito Murao, Takuji Nakano, Yuko Mizuno, Hiroaki Shimazaki, Toshiki Kan, Kazunori Nakaoka, Yuka Takagawa, Masashi Ohki, Naohiro Ichino, Keisuke Osakabe, Kentaro Yoshioka

研究成果: Article

23 引用 (Scopus)

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AIM: To investigate the factors other than fibrosis stage correlating with acoustic radiation force impulse (ARFI) elastograpy in chronic hepatitis C. METHODS: ARFI elastograpy was performed in 108 consecutive patients with chronic hepatitis C who underwent a liver biopsy. The proportion of fibrosis area in the biopsy specimens was measured by computerassisted morphometric image analysis. RESULTS: ARFI correlated significantly with fibrosis stage (β = 0.1865, P < 0.0001) and hyaluronic acid levels (β = 0.0008, P = 0.0039) in all patients by multiple regression analysis. Fibrosis area correlated sigsignificantly with ARFI by Spearman's rank correlation test but not by multiple regression analysis. ARFI correlated significantly with body mass index (BMI) (β = -0.0334, P = 0.0001) in F 0 or F 1, with γ-glutamyltranspeptidase levels (β = 0.0048, P = 0.0012) in F 2, and with fibrosis stage (β = 0.2921, P = 0.0044) and hyaluronic acid levels (β = 0.0012, P = 0.0025) in F 3 or F 4. The ARFI cutoff value was 1.28 m/s for F ≥ 2, 1.44 m/s for F ≥ 3, and 1.73 m/s for F 4. CONCLUSION: ARFI correlated with fibrosis stage and hyaluronic acid but not with inflammation. ARFI was affected by BMI, γ-glutamyltranspeptidase, and hyaluronic acid in each fibrosis stage.

元の言語English
ページ(範囲)1289-1297
ページ数9
ジャーナルWorld Journal of Gastroenterology
20
発行部数5
DOI
出版物ステータスPublished - 07-02-2014

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Gastroenterology

これを引用

Nishikawa, T., Hashimoto, S., Kawabe, N., Harata, M., Nitta, Y., Murao, M., Nakano, T., Mizuno, Y., Shimazaki, H., Kan, T., Nakaoka, K., Takagawa, Y., Ohki, M., Ichino, N., Osakabe, K., & Yoshioka, K. (2014). Factors correlating with acoustic radiation force impulse elastography in chronic hepatitis C. World Journal of Gastroenterology, 20(5), 1289-1297. https://doi.org/10.3748/wjg.v20.i5.1289