TY - JOUR
T1 - Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation
AU - Wu, Wudelehu
AU - Tsuchida, Hiromi
AU - Kato, Takehiro
AU - Niwa, Horoyuki
AU - Horikawa, Yukio
AU - Takeda, Jun
AU - Iizuka, Katsumi
N1 - Funding Information:
We thank Dr. Masahito Shimizu for critical reading of this manuscript. This work was supported by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (Horikawa Y: No. 25293228 , Takeda J: No. 26293246 , Iizuka K: No. 26500005 ).
Publisher Copyright:
© 2015 Elsevier Inc. All rights reserved.
PY - 2015/6/12
Y1 - 2015/6/12
N2 - We investigated the contributions of dietary fat and dietary carbohydrate to the development of fatty liver induced by western diet (WD). Compared with WD-fed wild type (WT) mice, livers of WD-fed ChREBP-/- mice showed lipid droplets of varying sizes around the hepatic lobules, while hepatic triglyceride and cholesterol contents were only modestly decreased. Inflammation and fibrosis were suppressed in ChREBP-/- mice. In addition, compared with WD-fed WT mice, ChREBP-/- mice showed decreased β-oxidation, ketogenesis and FGF21 production, increased intestinal lipid absorption, and decreased VLDL secretion. These findings suggest that dietary fat and carbohydrate contribute differently to the development of fatty liver.
AB - We investigated the contributions of dietary fat and dietary carbohydrate to the development of fatty liver induced by western diet (WD). Compared with WD-fed wild type (WT) mice, livers of WD-fed ChREBP-/- mice showed lipid droplets of varying sizes around the hepatic lobules, while hepatic triglyceride and cholesterol contents were only modestly decreased. Inflammation and fibrosis were suppressed in ChREBP-/- mice. In addition, compared with WD-fed WT mice, ChREBP-/- mice showed decreased β-oxidation, ketogenesis and FGF21 production, increased intestinal lipid absorption, and decreased VLDL secretion. These findings suggest that dietary fat and carbohydrate contribute differently to the development of fatty liver.
UR - http://www.scopus.com/inward/record.url?scp=84937759992&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84937759992&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2015.04.092
DO - 10.1016/j.bbrc.2015.04.092
M3 - Article
C2 - 25931000
AN - SCOPUS:84937759992
VL - 461
SP - 681
EP - 686
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 4
ER -