Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation

Wudelehu Wu, Hiromi Tsuchida, Takehiro Kato, Horoyuki Niwa, Yukio Horikawa, Jun Takeda, Katsumi Iizuka

研究成果: Article査読

22 被引用数 (Scopus)

抄録

We investigated the contributions of dietary fat and dietary carbohydrate to the development of fatty liver induced by western diet (WD). Compared with WD-fed wild type (WT) mice, livers of WD-fed ChREBP-/- mice showed lipid droplets of varying sizes around the hepatic lobules, while hepatic triglyceride and cholesterol contents were only modestly decreased. Inflammation and fibrosis were suppressed in ChREBP-/- mice. In addition, compared with WD-fed WT mice, ChREBP-/- mice showed decreased β-oxidation, ketogenesis and FGF21 production, increased intestinal lipid absorption, and decreased VLDL secretion. These findings suggest that dietary fat and carbohydrate contribute differently to the development of fatty liver.

本文言語English
ページ(範囲)681-686
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
461
4
DOI
出版ステータスPublished - 12-06-2015
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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