Fatal acute myocarditis in an infant with human herpesvirus 6 infection

T. Yoshikawa, M. Ihira, K. Suzuki, S. Suga, H. Kito, T. Iwasaki, T. Kurata, T. Tanaka, Y. Saito, Y. Asano

研究成果: Article査読

39 被引用数 (Scopus)


A 5 month old girl had typical clinical features of acute myocarditis just after the febrile period of exanthem subitum and died immediately. She had been healthy, with normal development, and there was no family history of particular note. Myocardial postmortem findings were compatible with acute myocarditis. Although the isolation of human herpesvirus 6 (HHV-6) was not attempted, positive IgM antibody to HHV-6 was detected in the patient's serum. Moreover, HHV-6 variant B DNA was detected in several tissues, including myocardium, by the polymerase chain reaction (PCR). In contrast, antibody responses to human herpesvirus 7, another causal agent of exanthem subitum, were not found, and enteroviral RNA was not detected in myocardial tissues by reverse transcription PCR. Apoptotic changes were seen in infiltrating cells within the myocardial tissues by means of the TUNEL method. HHV-6 antigen was not detected in several tissues (including myocardium) by immunohistochemical analysis. In conclusion, HHV-6 may have been the causative agent of fatal acute myocarditis in this infant.

ジャーナルJournal of Clinical Pathology
出版ステータスPublished - 2001

All Science Journal Classification (ASJC) codes

  • 病理学および法医学


「Fatal acute myocarditis in an infant with human herpesvirus 6 infection」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。