Feasibility and safety of hydrogen gas inhalation for post-cardiac arrest syndrome-first-in-human pilot study

Tomoyoshi Tamura; Kei Hayashida; Motoaki Sano; Masaru Suzuki; Takayuki Shibusawa; Joe Yoshizawa; Yosuke Kobayashi; Takeshi Suzuki; Shigeo Ohta; Hiroshi Morisaki; Keiichi Fukuda; Shingo Hori

doi:10.1253/circj.CJ-16-0127

Feasibility and safety of hydrogen gas inhalation for post-cardiac arrest syndrome-first-in-human pilot study

Tomoyoshi Tamura, Kei Hayashida, Motoaki Sano, Masaru Suzuki, Takayuki Shibusawa, Joe Yoshizawa, Yosuke Kobayashi, Takeshi Suzuki, Shigeo Ohta, Hiroshi Morisaki, Keiichi Fukuda, Shingo Hori

医学部・総合消化器外科学

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

64 被引用数 (Scopus)

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Background: Hydrogen gas inhalation (HI) ameliorates cerebral and cardiac dysfunction in animal models of postcardiac arrest syndrome (PCAS). HI for human patients with PCAS has never been studied. Methods and Results: Between January 2014 and January 2015, 21 of 107 patients with out-of-hospital cardiac arrest achieved spontaneous return of circulation. After excluding 16 patients with specific criteria, 5 patients underwent HI together with target temperature management (TTM). No undesirable effects attributable to HI were observed and 4 patients survived 90 days with a favorable neurological outcome. Conclusions: HI in combination with TTM is a feasible therapy for patients with PCAS.

本文言語	英語
ページ（範囲）	1870-1873
ページ数	4
ジャーナル	Circulation Journal
巻	80
号	8
DOI	https://doi.org/10.1253/circj.CJ-16-0127
出版ステータス	出版済み - 2016

All Science Journal Classification (ASJC) codes

循環器および心血管医学

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10.1253/circj.CJ-16-0127

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title = "Feasibility and safety of hydrogen gas inhalation for post-cardiac arrest syndrome-first-in-human pilot study",

abstract = "Background: Hydrogen gas inhalation (HI) ameliorates cerebral and cardiac dysfunction in animal models of postcardiac arrest syndrome (PCAS). HI for human patients with PCAS has never been studied. Methods and Results: Between January 2014 and January 2015, 21 of 107 patients with out-of-hospital cardiac arrest achieved spontaneous return of circulation. After excluding 16 patients with specific criteria, 5 patients underwent HI together with target temperature management (TTM). No undesirable effects attributable to HI were observed and 4 patients survived 90 days with a favorable neurological outcome. Conclusions: HI in combination with TTM is a feasible therapy for patients with PCAS.",

author = "Tomoyoshi Tamura and Kei Hayashida and Motoaki Sano and Masaru Suzuki and Takayuki Shibusawa and Joe Yoshizawa and Yosuke Kobayashi and Takeshi Suzuki and Shigeo Ohta and Hiroshi Morisaki and Keiichi Fukuda and Shingo Hori",

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volume = "80",

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T1 - Feasibility and safety of hydrogen gas inhalation for post-cardiac arrest syndrome-first-in-human pilot study

AU - Tamura, Tomoyoshi

AU - Hayashida, Kei

AU - Sano, Motoaki

AU - Suzuki, Masaru

AU - Shibusawa, Takayuki

AU - Yoshizawa, Joe

AU - Kobayashi, Yosuke

AU - Suzuki, Takeshi

AU - Ohta, Shigeo

AU - Morisaki, Hiroshi

AU - Fukuda, Keiichi

AU - Hori, Shingo

PY - 2016

Y1 - 2016

N2 - Background: Hydrogen gas inhalation (HI) ameliorates cerebral and cardiac dysfunction in animal models of postcardiac arrest syndrome (PCAS). HI for human patients with PCAS has never been studied. Methods and Results: Between January 2014 and January 2015, 21 of 107 patients with out-of-hospital cardiac arrest achieved spontaneous return of circulation. After excluding 16 patients with specific criteria, 5 patients underwent HI together with target temperature management (TTM). No undesirable effects attributable to HI were observed and 4 patients survived 90 days with a favorable neurological outcome. Conclusions: HI in combination with TTM is a feasible therapy for patients with PCAS.

AB - Background: Hydrogen gas inhalation (HI) ameliorates cerebral and cardiac dysfunction in animal models of postcardiac arrest syndrome (PCAS). HI for human patients with PCAS has never been studied. Methods and Results: Between January 2014 and January 2015, 21 of 107 patients with out-of-hospital cardiac arrest achieved spontaneous return of circulation. After excluding 16 patients with specific criteria, 5 patients underwent HI together with target temperature management (TTM). No undesirable effects attributable to HI were observed and 4 patients survived 90 days with a favorable neurological outcome. Conclusions: HI in combination with TTM is a feasible therapy for patients with PCAS.

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Feasibility and safety of hydrogen gas inhalation for post-cardiac arrest syndrome-first-in-human pilot study

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