Feasibility of the automated column agglutination technique for titration of anti-A/B antibodies in ABO-incompatible living kidney transplantation

Hideaki Matsuura, Yukari Sugiura, Takahiro Matsuno, Yume Tomiya, Mari Shiraki, Chiaki Kato, Keiko Ishihara, Harue Fukami, Reiko Niwa, Megumi Hayashi, Tadashi Matsushita, Hidefumi Kato, Yoshihiko Watarai, Taihei Ito, Takashi Kenmochi, Sumie Fujii, Yasuo Miura

研究成果: Article査読

抄録

Introduction: Quantitative measurement of anti-A/-B antibody titers is important during ABO-incompatible living kidney transplantation (ABOi-LKT). Methods: We conducted a multi-institutional study to measure the antibody titers using the automated column agglutination technique (auto-CAT) and tube test (TT) method in ABOi-LKT recipients. Statistical analysis was performed to evaluate the two methods. Results: We examined 111 samples from 35 ABOi-LKT recipients at four institutions. The correlation coefficient of the two methods was >0.9; the concordance rate and clinically acceptable concordance rate for the IgG titers were 60.4% and 88.3%, respectively. Perioperative status did not influence the statistical significance. Parallel changes were observed in the IgG antibody titers measured using the auto-CAT or TT technique by desensitizing therapy in time-course monitoring. Conclusion: Auto-CAT is comparable with the TT technique and is feasible for IgG anti-A/B antibody titration in ABOi-LKT recipients.

本文言語English
ページ(範囲)827-835
ページ数9
ジャーナルTherapeutic Apheresis and Dialysis
26
4
DOI
出版ステータスPublished - 08-2022

All Science Journal Classification (ASJC) codes

  • 血液学
  • 腎臓病学

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