FEES-based assessment of pharyngeal hypesthesia—Proposal and validation of a new test procedure

Bendix Labeit, Paul Muhle, Mao Ogawa, Inga Claus, Thomas Marian, Sonja Suntrup-Krueger, Tobias Warnecke, Jens Burchard Schroeder, Rainer Dziewas

研究成果: Article

2 引用 (Scopus)

抜粋

Background: Intact pharyngeal sensation is essential for a physiological swallowing process, and conversely, pharyngeal hypesthesia can cause dysphagia. This study introduces and validates a diagnostic test to quantify pharyngeal hypesthesia. Methods: A total of 20 healthy volunteers were included in a prospective study. Flexible endoscopic evaluation of swallowing (FEES) and a sensory test were performed both before and after pharyngeal local anesthesia. To test pharyngeal sensation, a small tube was positioned transnasally in the upper third of the oropharynx with contact to the lateral pharyngeal wall. Increasing volumes of blue-dyed water were injected through the tube, and the latency of swallowing response (LSR) was determined by two independent raters from the endoscopic video recording. Three trials were performed for each administered volume starting with 0.1 mL and increased by 0.1 mL up to 0.5 mL. Key Results: The average LSR without anesthesia was 2.24 ± 0.80 s at 0.1 mL, 1.79 ± 0.84 s at 0.2 mL, 1.29 ± 0.62 s at 0.3 mL, 1.17 ± 0.41 s at 0.4 mL, and 1.19 ± 0.52 s at 0.5 mL. With anesthesia applied, the average LSR was 2.65 ± 0.62 s at 0.1 mL, 2.64 ± 0.49 s at 0.2 mL, 2.44 ± 0.65 s at 0.3 mL, 2.10 ± 0.80 s at 0.4 mL, and 2.18 ± 0.85 s at 0.5 mL. LSR was significantly longer following anesthesia at 0.2 mL (t = −3.82; P =.001), 0.3 mL (t = −4.65; P <.000), 0.4 mL (t = −5.77; P <.000), and 0.5 mL (t = −3.49; P =.005). Conclusion and Inferences: Pharyngeal hypesthesia can be quantified with sensory testing using LSR. Suitable volumes to distinguish between normal and impaired pharyngeal sensation are 0.2 mL, 0.3 mL, 0.4 mL and 0.5 mL. Experimentally induced pharyngeal anesthesia represents a valid model of sensory dysphagia.

元の言語English
記事番号e13690
ジャーナルNeurogastroenterology and Motility
31
発行部数11
DOI
出版物ステータスPublished - 01-11-2019

All Science Journal Classification (ASJC) codes

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

フィンガープリント FEES-based assessment of pharyngeal hypesthesia—Proposal and validation of a new test procedure' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Labeit, B., Muhle, P., Ogawa, M., Claus, I., Marian, T., Suntrup-Krueger, S., Warnecke, T., Schroeder, J. B., & Dziewas, R. (2019). FEES-based assessment of pharyngeal hypesthesia—Proposal and validation of a new test procedure. Neurogastroenterology and Motility, 31(11), [e13690]. https://doi.org/10.1111/nmo.13690