Fibro-fatty volume of culprit lesions in virtual histology intravascular ultrasound is associated with the amount of debris during carotid artery stenting

Shoji Matsumoto, Ichiro Nakahara, Toshio Higashi, Yasushi Iwamuro, Yoshihiko Watanabe, Masahiro Takezawa, Daiki Murata, Tadaaki Yokota, Jun Ichi Kira, Takeshi Yamada

研究成果: ジャーナルへの寄稿学術論文査読

14 被引用数 (Scopus)

抄録

Objectives: This study aimed to evaluate the relationship between the amount of aspirated debris during distal balloon-protected carotid artery stenting (CAS) and the pre-intervention plaque composition, as assessed by Virtual Histology (VH) intravascular ultrasound (IVUS). Methods: The study subjects were 25 consecutive patients (mean age, 73.0 ± 5.2 years; 20 males and 5 females) who underwent CAS under distal balloon protection. The average rate of carotid stenosis was 74.6 ± 12.9% by North American Symptomatic Carotid Endarterectomy Trial criteria. We assessed culprit plaque components by VH-IVUS before CAS. Aspirated debris was filtered, stained with HE and mounted onto glass slides. The quantity of debris was evaluated by measuring its surface area. We evaluated the relationship between the quantity of aspirated debris and VH-IVUS measurements before CAS. Results: The amount of debris during CAS was positively correlated with the total plaque volume in grayscale IVUS (Rs = 0.480, p = 0.015) and fibro-fatty volumes over the entire lesion length in VH-IVUS (Rs = 0.561, p = 0.001). Conclusions: Culprit lesions with large plaque volumes, especially larger fibro-fatty volumes, as imaged by VH-IVUS, are associated with large amounts of debris during balloon-protected CAS.

本文言語英語
ページ(範囲)468-475
ページ数8
ジャーナルCerebrovascular Diseases
29
5
DOI
出版ステータス出版済み - 04-2010
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経学
  • 臨床神経学
  • 循環器および心血管医学

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