First evidence for accumulation of protein-bound and protein-free pyrraline in human uremic plasma by mass spectrometry

Hiroko Odani, Toru Shinzato, Yoshihiro Matsumoto, Ichiro Takai, Shigeru Nakai, Masamiki Miwa, Norihisa Iwayama, Izumi Amano, Kenji Maeda

研究成果: Article査読

27 被引用数 (Scopus)

抄録

Glucose-derived advanced glycation end products (AGEs) cross-link proteins and cause various biological tissue damage. One of them, pyrraline [ε-2-(formyl-5-hydroxymethyl-pyrrol-1-yl) has been demonstrated by utilizing antibody to accumulate in plasma and sclerosed matrix of diabetic individuals, suggesting responsibility for diabetic complications. To elucidate the involvement of pyrraline in uremia, we examined the pyrraline levels in patients with chronic renal failure by a mass spectrometric approach. Here we show that protein-free pyrraline as well as pyrraline with binding protein are significantly increased in non-diabetic uremic plasma compared to healthy subjects. Our results suggest that circulating pyrraline could be a substance contributing to complications in uremia.

本文言語English
ページ(範囲)237-241
ページ数5
ジャーナルBiochemical and Biophysical Research Communications
224
1
DOI
出版ステータスPublished - 05-07-1996
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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