TY - JOUR
T1 - Five cases of hereditary high red cell membrane phosphatidylcholine hemolytic anemia in three families
AU - Wakita, M.
AU - Matsui, T.
AU - Tsuzuki, M.
AU - Nomura, T.
AU - Miyazaki, H.
AU - Kojima, H.
AU - Maruyama, F.
AU - Okamoto, M.
AU - Ino, T.
AU - Ezaki, K.
AU - Sugihara, T.
AU - Kanzaki, A.
AU - Yawata, Y.
AU - Hirano, M.
N1 - Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 1996/3
Y1 - 1996/3
N2 - Five cases of hereditary high red cell membrane phosphatidylcholine hemolytic anemia in three families were described. All cases were clinically manifested by jaundice and splenomegaly. Hemolysis was evident from indirect hyperbilrubinemia, reticulocytosis and decrement of serum haptoglobin. Red blood cells showed morphological abnormalities such as poikylocytosis, anisocytosis and target cells on blood smears. Both direct and indirect Coombs' tests were negative. Ham test, sugar water test and hemoglobin electrophoresis showed no abnormalities. Osmotic fragility test showed decreased membrane fragility. Lipid analysis of red cell membrane showed increment of phosphatidylcholine content and decrement of sphingomyelin content, although plasma lipids were essentially normal. Influx and efflux of sodium through the red cell membrane were both increased. Splenectomy was performed without effect on one patient and the mother of other patients.
AB - Five cases of hereditary high red cell membrane phosphatidylcholine hemolytic anemia in three families were described. All cases were clinically manifested by jaundice and splenomegaly. Hemolysis was evident from indirect hyperbilrubinemia, reticulocytosis and decrement of serum haptoglobin. Red blood cells showed morphological abnormalities such as poikylocytosis, anisocytosis and target cells on blood smears. Both direct and indirect Coombs' tests were negative. Ham test, sugar water test and hemoglobin electrophoresis showed no abnormalities. Osmotic fragility test showed decreased membrane fragility. Lipid analysis of red cell membrane showed increment of phosphatidylcholine content and decrement of sphingomyelin content, although plasma lipids were essentially normal. Influx and efflux of sodium through the red cell membrane were both increased. Splenectomy was performed without effect on one patient and the mother of other patients.
UR - https://www.scopus.com/pages/publications/0030099234
UR - https://www.scopus.com/pages/publications/0030099234#tab=citedBy
M3 - Article
C2 - 8727354
AN - SCOPUS:0030099234
SN - 0485-1439
VL - 37
SP - 265
EP - 270
JO - [Rinshō ketsueki] The Japanese journal of clinical hematology
JF - [Rinshō ketsueki] The Japanese journal of clinical hematology
IS - 3
ER -