Five cases of locally advanced rectal cancer or local recurrence performed intra-arterial infusion chemotherapy via the internal iliac artery

Yoshikaze Koide, Koutaro Maeda, Tsunekazu Hanai, Harunobu Sato, Kouji Masumori, Hiroyuki Aoyama, Hidetoshi Katsuno, Masuo Funabashi, Toshiaki Kamano, Toshihisa Agata, Tomohito Noro

研究成果: Article査読

抄録

Intra-arterial infusion chemotherapy via the internal iliac artery was performed in 5 patients with locally advanced rectal cancer or recurrent rectal cancer. Arterial infusion chemotherapy was conducted into the internal iliac artery via bilateral femoral artery following a blood flow change with a coil. 5 FU 500 mg and l-leucovorin 125 mg/m2 were injected weekly. An average time of injections or its duration was 40 (17-74) times or 12.8 (5-23) months, respectively. Disappearance or improvement of symptoms was observed in 4 cases. A decrease of tumor size observed by CT was in 2 cases and a decrease of blood CEA level was in 3 cases. As for the complication of arterial infusion chemotherapy, dermatopathy was found in all of the cases, and sensory disturbance of lower extremities was in 3 cases, infection was in 2 cases and catheter obstruction was in 2 cases. A decrease of dosage or abundance of continuation was done during the course due to complications. Two patients with primary cancer died 1-3 years after the treatment, and 2 patients with recurrence died 7 months to 1 year after the treatment. One patient with primary cancer is continuing the treatment for the last 2 years though multiple metastatic diseases have been confirmed.

本文言語English
ページ(範囲)1718-1720
ページ数3
ジャーナルGan to kagaku ryoho. Cancer & chemotherapy
32
11
出版ステータスPublished - 10-2005

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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