Five cases of thrombocytopenia induced by primary human herpesvirus 6 infection

Tetsushi Yoshikawa; Masashi Morooka; Sadao Suga; Yukihiko Niinomi; Tetsuichi Kaneko; Kunihiro Shinoda; Yoshiyuki Muraki; Koji Takahashi; Norio Sugaya; Yoshizo Asano

doi:10.1111/j.1442-200X.1998.tb01928.x

Five cases of thrombocytopenia induced by primary human herpesvirus 6 infection

Tetsushi Yoshikawa, Masashi Morooka, Sadao Suga, Yukihiko Niinomi, Tetsuichi Kaneko, Kunihiro Shinoda, Yoshiyuki Muraki, Koji Takahashi, Norio Sugaya, Yoshizo Asano

小児科学

研究成果: Article › 査読

12 被引用数 (Scopus)

抄録

Abstract Five patients suffering from exanthem subitum with thrombocytopenia were confirmed as primary human herpesvirus 6 (HHV-6) infection by serological test. All cases had thrombocytopenia during the acute phase of exanthem subitum. The clinical features of these cases were benign, and all recovered without any specific treatment. Moreover. 4 of the 5 cases showed a mild elevation of hepatic transaminase during the same period, and other viral infections including cytomegalovirus, Epstein-Barr virus, and human herpesvirus 7 were ruled out in these patients. It was speculated that direct inhibition of platelet production by the virus or cytokine induced by the virus-infected cells was the mechanism of the thrombocytopenia induced by primary HHV-6 infection.

本文言語	English
ページ（範囲）	278-281
ページ数	4
ジャーナル	Pediatrics International
巻	40
号	3
DOI	https://doi.org/10.1111/j.1442-200X.1998.tb01928.x
出版ステータス	Published - 06-1998

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health

文献へのアクセス

10.1111/j.1442-200X.1998.tb01928.x

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引用スタイル

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title = "Five cases of thrombocytopenia induced by primary human herpesvirus 6 infection",

abstract = "Abstract Five patients suffering from exanthem subitum with thrombocytopenia were confirmed as primary human herpesvirus 6 (HHV-6) infection by serological test. All cases had thrombocytopenia during the acute phase of exanthem subitum. The clinical features of these cases were benign, and all recovered without any specific treatment. Moreover. 4 of the 5 cases showed a mild elevation of hepatic transaminase during the same period, and other viral infections including cytomegalovirus, Epstein-Barr virus, and human herpesvirus 7 were ruled out in these patients. It was speculated that direct inhibition of platelet production by the virus or cytokine induced by the virus-infected cells was the mechanism of the thrombocytopenia induced by primary HHV-6 infection.",

author = "Tetsushi Yoshikawa and Masashi Morooka and Sadao Suga and Yukihiko Niinomi and Tetsuichi Kaneko and Kunihiro Shinoda and Yoshiyuki Muraki and Koji Takahashi and Norio Sugaya and Yoshizo Asano",

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T1 - Five cases of thrombocytopenia induced by primary human herpesvirus 6 infection

AU - Yoshikawa, Tetsushi

AU - Morooka, Masashi

AU - Suga, Sadao

AU - Niinomi, Yukihiko

AU - Kaneko, Tetsuichi

AU - Shinoda, Kunihiro

AU - Muraki, Yoshiyuki

AU - Takahashi, Koji

AU - Sugaya, Norio

AU - Asano, Yoshizo

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N2 - Abstract Five patients suffering from exanthem subitum with thrombocytopenia were confirmed as primary human herpesvirus 6 (HHV-6) infection by serological test. All cases had thrombocytopenia during the acute phase of exanthem subitum. The clinical features of these cases were benign, and all recovered without any specific treatment. Moreover. 4 of the 5 cases showed a mild elevation of hepatic transaminase during the same period, and other viral infections including cytomegalovirus, Epstein-Barr virus, and human herpesvirus 7 were ruled out in these patients. It was speculated that direct inhibition of platelet production by the virus or cytokine induced by the virus-infected cells was the mechanism of the thrombocytopenia induced by primary HHV-6 infection.

AB - Abstract Five patients suffering from exanthem subitum with thrombocytopenia were confirmed as primary human herpesvirus 6 (HHV-6) infection by serological test. All cases had thrombocytopenia during the acute phase of exanthem subitum. The clinical features of these cases were benign, and all recovered without any specific treatment. Moreover. 4 of the 5 cases showed a mild elevation of hepatic transaminase during the same period, and other viral infections including cytomegalovirus, Epstein-Barr virus, and human herpesvirus 7 were ruled out in these patients. It was speculated that direct inhibition of platelet production by the virus or cytokine induced by the virus-infected cells was the mechanism of the thrombocytopenia induced by primary HHV-6 infection.

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